Results 81 to 90 of about 270,992 (264)
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Two Stages of Arrival Aircraft: Influencing Factors and Prediction of Integrated Arrival Time
To enhance the accuracy and real-time capability of estimated in-block time (EIBT) predictions at airports, this study proposes a two-stage integrated prediction method.
Xiaowei Tang +3 more
doaj +1 more source
Underground positioning method of single base station DOA and TOA based on single reflectio
In view of problem of big error in underground single base station positioning system due to wireless signal influenced by multipath effect and non-line of sight, a joint estimation positioning method of DOA and TOA based on single reflection was ...
HUANG Kai +3 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Currently there is a growing demand for accurate and reliable positioning indoors or in other environments, where Global Navigation Satellite Systems (GNSS) are unavailable.
Josef Krska +2 more
doaj +1 more source
To find the relative positional relationship accurately and efficiently without pre-installed infrastructure in emergent scenarios like firefighting, we proposed a rotating-anchor based indoor geolocation system using time of arrival (TOA) technique in ...
Liyuan Xu +5 more
doaj +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Robust Time-of-Arrival Location Estimation Algorithms for Wildlife Tracking. [PDF]
Arnon E +5 more
europepmc +1 more source

