Results 101 to 110 of about 314,397 (335)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Pulse Arrival Time - A Sensitive Vital Parameter for the Detection of Mental Stress [PDF]
, 2021 Hannes Ernst +3 more
openalex +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
, 2008 Repeated measurements of a quantum particle to check its presence in a region of space was proposed long ago [G. R. Allcock, Ann. Phys. {\bf 53}, 286 (1969)] as a natural way to determine the distribution of times of arrival at the orthogonal subspace ...
A. del Campo +5 more
core +1 more source
Constrained Weighted Least-Squares Algorithms for 3-D AOA-Based Hybrid Localization
IEEE Open Journal of Signal ProcessingSource localization with time-of-arrival (TOA), time-difference-of-arrival (TDOA), time-delay (TD), received-signal-strength (RSS), or angle-of-arrival (AOA) measurements from several spatially distributed sensors is commonly used in practice.
Yanbin Zou +3 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Machine Learning Estimation of Fire Arrival Time from Level-2 Active Fires Satellite Data [PDF]
, 2021 Angel Farguell +5 more
openalex +1 more source
Underground positioning method of single base station DOA and TOA based on single reflectio
Gong-kuang zidonghua, 2015 In view of problem of big error in underground single base station positioning system due to wireless signal influenced by multipath effect and non-line of sight, a joint estimation positioning method of DOA and TOA based on single reflection was ...
HUANG Kai +3 more
doaj +1 more source