Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Time-resolved X-ray powder diffraction study of polymorphism in colbate nitrate hexahydrate and phase transformations at low temperatures [PDF]
, 1993 J. Plévert +2 more
openalex +1 more source
The distinction between star clusters and associations
, 2010 In Galactic studies a distinction is made between (open) star clusters and associations. For barely resolved objects at a distance of several Mpc this distinction is not trivial to make. Here we provide an objective definition by comparing the age of the
Ambartsumian +10 more
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Physical Review Accelerators and BeamsIn low-energy beam transport of pulsed, high-perveance ion beams operating under neutralized space-charge conditions, understanding the time required for the compensation process to develop—known as the build-up time—is critically important for ensuring ...
Emre Cosgun +4 more
doaj +1 more source
Time-resolved fluorescence anisotropy as a tool to study guest–cucurbit[n]uril—protein ternary supramolecular interactions [PDF]
, 2015 Karina Scholtbach +3 more
openalex +1 more source
Feasibility experiments on time-resolved fluorosensing applied to oil slicks [PDF]
, 1986 The introduction of time resolved observations can provide a very penetrating tool in the practice of laser fluorosensing. The investigations have demonstrated a relevance of multispectral, time resolved analysis for oil fingerprinting.
Camagni, P. +5 more
core +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Time-resolved FTIR difference spectroscopy for the study of photosystem I with high potential naphthoquinones incorporated into the A1 binding site [PDF]
, 2022 Neva Agarwala +2 more
openalex +1 more source