Results 101 to 110 of about 1,006,043 (267)

Controllability Scores of Linear Time-Varying Network Systems

IEEE Transactions on Automatic Control
For large-scale network systems, network centrality based on control theory plays a crucial role in understanding their properties and controlling them efficiently. The controllability score is such a centrality index and can give a physically meaningful measure.
Kota Umezu, Kazuhiro Sato
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

A robust control strategy for mixed traffic systems with time-varying delays and uncertainties

Journal of King Saud University: Computer and Information Sciences
In mixed traffic environments, connected and automated vehicles (CAVs) are subject to time-varying delays arising from wireless communication, data processing, and driving tasks.
Xiaodi Wang, Xuan Cai, Zhiwei Guo, Shuxin Liu   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Understanding zoonotic disease spread with a fractional order epidemic model

Scientific Reports
Zoonotic diseases, which are transmitted between animals and humans, pose significant public health challenges, especially in regions with high human-wildlife interactions.
Mohammed Althubyani, Haroon D. S. Adam, Ahmad Alalyani, Nidal E. Taha, Khdija O. Taha, Rasmiyah A. Alharbi, Sayed Saber   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Adaptive Output Regulation for Permanent Magnet Synchronous Motor (PMSM) Speed Servo System via Time-Varying Internal Model Approach

Actuators
This article investigates the adaptive output regulation problem of a permanent magnet synchronous motor (PMSM) speed servo system with unknown time-varying exosystems and aims to achieve multiple objectives including speed tracking, disturbance ...
Hui Song, Zhaowu Ping, Jiaze Hui, Yunzhi Huang, Jun-Guo Lu   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source