Results 111 to 120 of about 2,626,429 (291)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Optimization control of time-varying cyber–physical systems via dynamic-triggered strategies

Results in Control and Optimization
A novel approach is proposed for designing control strategies for time-varying cyber–physical systems (CPSs) with unknown dynamics, eliminating the need for system identification.
Yuanshan Liu, Yude Xia
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

AN ALTERNATIVE METHOD FOR THE DESIGN OF TIME-VARYING FEEDBACK CONTROL SYSTEMS

Dyna, 2012
El presente artículo propone utilizar una estrategia numérica basada en un algoritmo de optimización metaheurístico de enjambre de partículas discreto, para resolver un problema de diseño de compensadores en sistemas retroalimentados variantes en el ...
CARLOS GÓMEZ, IVÁN AMAYA, RODRIGO CORREA   +2 more
doaj  

Robust Sliding Mode Control for Time-Varying Systems With Adaptive Prescribed Performance

IEEE Access
The system parameter variations will degrade the system performances, and they can not be estimated in time. This paper proposes a robust sliding mode control for time-varying systems with adaptive prescribed performance.
Hongjun Li, Shengjun Wen, Jun Yu, Hengyi Li   +3 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Finite-Time Adaptive Control of Nonstrict-Feedback Nonlinear Systems With Time-Varying Full State Constraints

IEEE Access
This paper proposes a finite-time adaptive tracking fuzzy control approach for nonlinear nonstrict-feedback systems with unknown disturbances and time-varying full state constraints.
Jiahuan Lv, Rui Zhang, Junmin Li, Jianmin Jiao, Yuan Cheng, Xuejie Yang   +5 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Prescribed-time stabilization of nonlinear systems with uncertainties/disturbances by improved time-varying feedback control

AIMS Mathematics
We address the prescribed-time stability of a class of nonlinear system with uncertainty/disturbance. With the help of the parametric Lyapunov equation (PLE), we designed a state feedback control to regulate the full-state of a controlled system within ...
Lichao Feng, Mengyuan Dai, Nan Ji, Yingli Zhang, Liping Du   +4 more
doaj   +1 more source