Results 101 to 110 of about 1,013,274 (291)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

On Robustness Analysis of a Dynamic Average Consensus Algorithm to Communication Delay

, 2018
This paper studies the robustness of a dynamic average consensus algorithm to communication delay over strongly connected and weight-balanced (SCWB) digraphs.
Kia, Solmaz S., Moradian, Hossein
core   +1 more source

General decay of the solution for a viscoelastic wave equation with a time-varying delay term in the internal feedback

, 2012
In this paper we consider a viscoelastic wave equation with a time-varying delay term, the coefficient of which is not necessarily positive. By introducing suitable energy and Lyapunov functionals, under suitable assumptions, we establish a general ...
Abdallah C., Berrimi S., Cavalcanti M. M., Cavalcanti M. M., Nicaise S., Nicaise S., Renardy M., Wenjun Liu   +7 more
core   +1 more source

Stability Bounds of Time-Varying Uncertainty and Delay Time for Discrete Systems with Time-Varying Delayed State [PDF]

Journal of Institute of Control, Robotics and Systems, 2012
Abstract: The stability robustness problem of linear discrete systems with time-varying unstructured uncertainty of delayed states with time-varying delay time is considered. The proposed conditions for stability can be used for finding allowable bounds of time-varying uncertainty and delay time, which are solved by using LMI (Linear Matrix Inequality)
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

On Average Values of Time-Varying Delays and a New Representation of Systems with Time-Varying Delays

2019 American Control Conference (ACC), 2019
We show by a counterexample that the asymptotic stability of a system with a pointwise periodic time-varying delay cannot be deduced from the average value of the delay. We use this counterexample to motivate our new representation of systems with time-varying delays, which we use to develop a new state feedback stabilization method.
Mazenc, Frédéric, Malisoff, Michael
openaire   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Delay-Dependent Robust Exponential Stability for Uncertain Neutral Stochastic Systems with Interval Time-Varying Delay

Journal of Applied Mathematics, 2012
This paper discusses the mean-square exponential stability of uncertain neutral linear stochastic systems with interval time-varying delays. A new augmented Lyapunov-Krasovskii functional (LKF) has been constructed to derive improved delay-dependent ...
Weihua Mao, Feiqi Deng, Anhua Wan
doaj   +1 more source

Time Delay Compensation Based Active Disturbance Rejection Control for Thermal Process

Chemical Engineering Transactions, 2019
Thermal process is typically nonlinear and uncertain. The control design becomes even more challenging in the presence of time-varying delay. Active disturbance rejection control (ADRC) has been shown to be an effective tool in dealing with real world ...
Fan Zhang, Yali Xue, Donghai Li, Zheng Li   +3 more
doaj   +1 more source