Results 81 to 90 of about 424,486 (315)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Finite-Time Stabilization of Memristive Cohen-Grossberg Neural Networks with Time-Varying Delay

open access: yesComplexity, 2018
In this paper, the finite-time stabilization problem for memristive Cohen-Grossberg neural networks with time-varying delay is discussed. By using the novel fixed point theory of set-valued maps, we establish the existence theorem of equilibrium point ...
Ge Li, Yaqiong Li, Zhaohui Yuan
doaj   +1 more source

Robust H∞ control of time-varying systems with stochastic non-linearities: the finite-horizon case

open access: yes, 2010
The official published version can be obtained from the link below.This paper is concerned with the robust H∞ control problem for the class of uncertain non-linear discrete time-varying stochastic systems with a covariance constraint.
Wang, Z, Ma, L, Bo, Y, Guo, Z
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Stability Analysis of Markovian Jump System With Multi-Time-Varying Disturbances Based on Improved Interactive Convex Inequality and Positive Definite Condition

open access: yesIEEE Access, 2019
Time-varying disturbances not only exist in the external delay of Markovian jump system but also may exist in the transfer rate of internal probability transfer.
Liankun Sun, Nuo Xu
doaj   +1 more source

SMC design for robust H∞ control of uncertain stochastic delay systems

open access: yes, 2010
Recently, sliding mode control method has been extended to accommodate stochastic systems. However, the existing results employ an assumption that may be too restrictive for many stochastic systems.
Huang, Lirong, Mao, Xuerong
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Discrete-time recurrent neural networks with time-varying delays: Exponential stability analysis

open access: yes, 2007
This is the post print version of the article. The official published version can be obtained from the link below - Copyright 2007 Elsevier LtdThis Letter is concerned with the analysis problem of exponential stability for a class of discrete-time ...
Liu, Y, Liu, X, Wang, Z, Serrano, A
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Further results on delay-dependent stability criteria of discrete systems with an interval time-varying delay

open access: yes, 2017
This paper deals with stability of discrete-time systems with an interval-like time-varying delay. By constructing a novel augmented Lyapunov functional and using an improved finite-sum inequality to deal with some sum-terms appearing in the forward ...
Wu, Min   +9 more
core   +1 more source

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