Results 91 to 100 of about 502,322 (291)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Delay‐Independent Stability of Switched Linear Systems withUnbounded Time‐Varying Delays [PDF]

Abstract and Applied Analysis, 2012
This paper is focused on delay‐independent stability analysis for a class of switched linear systems with time‐varying delays that can be unbounded. When the switched system is not necessarily positive, we first establish a delay‐independent stability criterion under arbitrary switching signal by using a new method that is different from the methods to
openaire   +4 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Estimation of communication-delays through adaptive synchronization of chaos

, 2011
This paper deals with adaptive synchronization of chaos in the presence of time-varying communication-delays. We consider two bidirectionally coupled systems that seek to synchronize through a signal that each system sends to the other one and is ...
Abarbanel, Annovazzi-Lodi, Argyris, Ashwin, Ashwin, Banerjee, Bharath Sundararaman, Boccaletti, Cao, Carroll, Carroll, Chen, Chen, Cohen, Creveling, Cuomo, De Lellis, De Lellis, Ding, Drakunov, Dronov, Duane, Feki, Francesco Sorrentino, Fujisaka, Gao, Ghosh, Hayes, He, Hunt, Hunt, Hunt, Jafari, Kakmeni, Kanter, Kapitaniak, Kayton, Kinzel, Li, Li, Lu, Murphy, Murphy, Ott, Pecora, Pecora, Pietro DeLellis, Pikovsky, Quinn, Ravoori, Restrepo, So, Sorrentino, Sorrentino, Sorrentino, Sorrentino, Sorrentino, Sorrentino, Strom, Sun, Tsimring, Uchida, Venkataramani, Vincent, Yassen, Yau, Yu, Yu, Yu, Yu, Zhou, Zhou, Zhu   +72 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dissipative Filtering for Stochastic Singular Time-Varying Delay Systems

IEEE Access, 2019
In this paper, we focus on discussing the delay-dependent dissipative filtering problem for a type of singular time-varying delay systems with random disturbance. At first, we construct a proper candidate Lyapunov-Krasovskii functional, then on the basis
Jingke Xu, Shuangyun Xing, Feiqi Deng
doaj   +1 more source

Robust controller design for ATM network with time - varying multiple time - delays [PDF]

, 2009
Makalenin ilk sayfası mevcuttur.For the congestion of the Asynchronous Transfer Mode (ATM) networks with time-varying multiple time-delays and changeful available bit-rate (ABR) bandwidth, an ABR flow controller is designed and the LMI-based delay ...
Dimirovski, Georgi M., Jing, Yuan-Wei, Luo, Xiaochuan, Ren, Tao, Wang, Chengen   +4 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Dissipative Stabilization of Linear Systems with Time-Varying General Distributed Delays (Complete Version)

, 2020
New methods are developed for the stabilization of a linear system with general time-varying distributed delays existing at the system's states, inputs and outputs.
Feng, Qian, Nguang, Sing Kiong, Perruquetti, Wilfrid   +2 more
core