Results 111 to 120 of about 502,322 (291)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

A Novel Approach to Delay-Variation-Dependent Stability Analysis of 2-D Discrete-Time Systems With Mixed Delays

open access: yesIEEE Access, 2019
In this paper, a stability analysis problem is studied for a class of two-dimensional (2-D) discrete-time systems with time-varying and distributed delays described by the second Fornasini-Marchesini (FM) model. First, new 2-D polynomials-based summation
Dan Peng, Hongshuang Xu
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Stability of cellular neural networks with unbounded time-varying delays

open access: yesElectronic Journal of Differential Equations, 2008
In this article, we prove the existence of local solutions and the stability of the equilibrium points for cellular neural networks.
Jianying Shao, Lijuan Wang
doaj  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

Robust stabilization for uncertain discrete–time singular Markovian jump systems with time–varying delays

open access: yesIET Control Theory & Applications
The stabilization problem for uncertain discrete‐time singular Markovian jump systems (DSMJSs) with time‐varying delays is comprehensively covered in this paper.
Wenbin Chen, Fang Gao
doaj   +1 more source

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