Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Improving the Robustness of Time Difference of Arrival Estimation Based on the Energy Center of Gravity Rearrangement. [PDF]
Sensors (Basel), 2023 Zhang P, Wen H, Xu Z, Zhao Z.
europepmc +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A Reliable Pipeline Leak Detection Method Using Acoustic Emission with Time Difference of Arrival and Kolmogorov-Smirnov Test. [PDF]
Sensors (Basel), 2023 Nguyen DT, Nguyen TK, Ahmad Z, Kim JM.
europepmc +1 more source
High-Precision Time Difference of Arrival Estimation Method Based on Phase Measurement
Remote SensingIn unmanned aerial vehicle (UAV)-based time difference of arrival (TDOA) positioning technique, baselines are limited due to communication constraints. In this case, the accuracy is highly sensitive to the TDOA measurements’ error. This article primarily
Jihao Xin +7 more
doaj +1 more source
Disturbance Source Location in Power Systems Based on Time Difference of Arrival
Zhongguo dianli, 2019 The system frequency dynamics in large-scale interconnected power grids are characterized by spatial-temporal distribution, and its propagation speed is far less than the light speed.
Mengxi WEI +4 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Research on a Method of Locating Civil Aviation Radio Interference Sources Based on Time Difference of Arrival and Frequency Difference of Arrival for Four Unmanned Aerial Vehicles. [PDF]
Sensors (Basel), 2023 Zhou C +6 more
europepmc +1 more source
Smart Passive Localization Using Time Difference of Arrival [PDF]
, 2016 A smart passive localization system using time difference of arrival (TDoA) measurements is designed and analyzed with the goal of providing the position information for the construction of frequency allocation ...
El Gemayel, Noha
core +1 more source