Results 161 to 170 of about 153,320 (330)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Based on the generalized cross-correlation method (GCC), the period peaks in the cross-correlation function (CCF) of frequency shift keying (FSK) signals will degrade the estimation performance of time difference of arrival (TDOA), as well as the ...
Qun Wan +3 more
core +1 more source
DIFFERENCE IN THE FREQUENCY OF ARRIVAL OF PATIENTS WITH COPD BY TIME PERIODS
, 2020 Kronična opstruktivna plućna bolest je veoma česta plućna bolest koja se može prevenirati i adekvatno liječiti, a obilježena je trajnim dišnim simptomima i smanjenim protokom zraka zbog abnormalnosti dišnih puteva.
Zdjelar, Sonja
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
A Two-Stage Aerial Target Localization Method Using Time-Difference-of-Arrival Measurements with the Minimum Number of Radars [PDF]
, 2023 Jinming Chen +7 more
openalex +1 more source
Valuation of uncertainty in travel time and arrival time - some findings from a choice experiment [PDF]
We are developing a dynamic modeling framework in which we can evaluate the effects of different road pricing measures on individual choice behavior as well as on a network level.
Michiel Bliemer, Dirk Van Amelsfort
core
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Load Position Estimation Method for Wearable Devices Based on Difference in Pulse Wave Arrival Time [PDF]
, 2022 Kazuki Yoshida, Kazuya Murao
openalex +1 more source