Results 121 to 130 of about 36,626,105 (254)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Bootstrapping frequency domain tests in multivariate time series with an application to comparing spectral densities [PDF]
We propose a general bootstrap procedure to approximate the null distribution of nonparametric frequency domain tests about the spectral density matrix of a multivariate time series.
Paparoditis, Efstathios, Dette, Holger
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
The time-domain response of coupled-resonator filters with applications to tuning [PDF]
, 2004 This thesis develops a new theory of tuning filters based on the time-domain response of the filter. These methods are shown to work very well for all-pole coupledresonator filters in particular, and may be applied to automated tuning of filters ...
Dunsmore, Joel Philip
core +1 more source
Impaired circadian heart rate variability in Parkinson's disease: a time-domain analysis in ambulatory setting. [PDF]
BMC Neurol, 2020 Arnao V +7 more
europepmc +1 more source
, 2001 Based on the Euler-Beam theory, the moving vehicle loads on bridges were identified from the response of bridges using the Time Domain MethQd (TDM) and Frequency-Time Domain Method (FTDM).
Chan, Tommy H.T., Yu, Ling, Law, S.S.
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
We provide a concise overview of time series analysis in the time and frequency domains, with lots of references for further reading.time series analysis, time domain, frequency ...
Marc Nerlove +2 more
core +2 more sources