Results 131 to 140 of about 36,626,105 (254)
Frequency domain error analysis in ultra-precision flycutting
, 2014 In some special fields such as precision optics, the part surface has strict requirements on the frequency domain errors, besides the conventional spatial domain errors such as surface roughness error.
Chen GD(陈国达) +4 more
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Journal of Communications Software and Systems, 2009 For different values of the decay constant in the Modified Transmission Line Model with Exponential Decay (MTLE) and for dierent channel heights the results for lightningelectromagnetic field (LEMF) at dierent distances fromthe channel-base are presented
V. Javor, P. D. Rančić
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
FDTD channel modelling with time domain huygens' technique [PDF]
, 2011 Much interest is currently being shown in mm-wave high data rate, short range communication links. The modelling of these types of links presents considerable challenges.
Paul, DL, Dumanli, S, Railton, CJ
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Analysis of electromagnetic wave propogation using 3D finite-difference time-domain methods with parallel processing. [PDF]
The 3D Finite-Difference Time-Domain (FDTD) method simulates structures in the time-domain using a direct form of Maxwell’s curl equations. This method has the advantage over other simulation methods in that it does not use empirical approximations ...
Buchanan, William J.
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source