Results 151 to 160 of about 5,380,901 (293)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Heart rate variability reveals graded task difficulty effects and sensitization dynamics in anticipatory psychological stress via time-domain analysis. [PDF]

J Physiol Anthropol
Jian Z, Huang J, Shi F, Shimomura Y.
europepmc   +1 more source

On Time Domain Analysis of Photoplethysmogram Signals for Monitoring Heat Stress. [PDF]

Sensors (Basel), 2015
Elgendi M, Fletcher R, Norton I, Brearley M, Abbott D, Lovell NH, Schuurmans D.   +6 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Time-Domain Analysis of Chest Impedance for Venous Air Embolism Detection: An Open-Source Software Tool and Single-Cadaver Pilot Study. [PDF]

Cureus
Marcellino C, Johnston M, Robinson N, Abcejo AS.   +3 more
europepmc   +1 more source

Time-domain analysis of scrotal thermoregulatory impairment in varicocele. [PDF]

Front Physiol, 2014
Ismail E, Orlando G, Pompa P, Gabrielli D, Di Donato L, Cardone D, Merla A.   +6 more
europepmc   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Time-Domain Analysis of Low- and High-Frequency Near-Infrared Spectroscopy Sensor Technologies for Characterization of Cerebral Pressure-Flow and Oxygen Delivery Physiology: A Prospective Observational Study. [PDF]

Sensors (Basel)
Sainbhi AS, Vakitbilir N, Bergmann T, Stein KY, Hasan R, Silvaggio N, Hayat M, Moon J, Zeiler FA.   +8 more
europepmc   +1 more source

Frequency and Time Domain Analysis of Foetal Heart Rate Variability with Traditional Indexes: A Critical Survey. [PDF]

Comput Math Methods Med, 2016
Romano M, Iuppariello L, Ponsiglione AM, Improta G, Bifulco P, Cesarelli M.   +5 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source