Results 141 to 150 of about 2,528,294 (311)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Time domain simulation of hydroelastic response of ships in large amplitude waves
, 2006 The influence of non-linearities on wave-induced motions and loads has been the focus of many investigations in the past few years and continues to be an important issue.
Park, Jae-Hong
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Use of domain-specific language in test automation [PDF]
, 2013 The primary aim of this research project was to investigate techniques to replace the complicated process of testing embedded systems in automotive domain.
Hussain, Ambreen
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Sensitivity Study on Parameters of Large-size Jacket Launching
Shiyou jixie, 2017 There are various parameters affecting the jacket launching trajectory and safety. In order to make the selection procedure of the parameter values faster and more accurate, the parameterized finite element simulation model has been established including
Wang Tianying, Jiang Ximin
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Simulation Study of Stochastic Wind Field of Catenaries with Spatial Correlativity
机车电传动, 2010 According to catenary construction, at unreduced precision, a multivariable simulation model of catenary stochastic pulsation wind field based on the harmonic synthesis was proposed, which properly simplifies wind speed coherence function and power ...
曹树森, 秦剑, 柯坚, 刘晓红
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Time-domain simulations for floating structures [PDF]
, 2009 In this thesis numerical and analytical investigations of wave-structure interactions are conducted within the linearised theory of water waves. The primary objective of the thesis was to develop a numerical time-domain solution method capable of ...
Colm J. Fitzgerald (7158557) +1 more
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