Results 61 to 70 of about 5,380,901 (293)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Fatigue life prediction of 316 stainless steel in simulated PWR primary water by time domain analysis based on short fatigue crack growth behavior

Mechanical Engineering Journal, 2017
The fatigue life of austenitic stainless steel is significantly reduced in the environment of a pressurized water reactor (PWR). One of the methods for evaluating the environmental effect involves the use of the environmental correction factor (Fen ...
Choongmoo SHIM, Yoichi TAKEDA, Tetsuo SHOJI   +2 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Time evolutions of scalar field perturbations in $D$-dimensional Reissner-Nordstr\"om Anti-de Sitter black holes

, 2016
Reissner-Nordstr\"om Anti-de Sitter (RNAdS) black holes are unstable against the charged scalar field perturbations due to the well-known superradiance phenomenon.
Li, Ran, Zhang, Hongbao, Zhao, Junkun
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A Novel Hybrid Analysis Method of LLC Resonant Converter for High Accuracy and Low Computational Burden

IEEE Access
Recently, as the demand for LLC resonant converters has increased in various power electronics industry sectors, research on accurate analysis methods necessary for effectively designing converters has been conducted.
Su-Seong Park, Rae-Young Kim
doaj   +1 more source

Identification and Location of PD Defects in Medium voltage Underground Power Cables Using High Frequency Current Transformer

IEEE Access, 2019
Fault location is an important diagnostic task in condition monitoring of underground medium voltage cables. Available solutions are well capable of determining the location of a single partial discharge (PD) defect on a cable section. In case several PD
Muhammad Shafiq, Ivar Kiitam, Paul Taklaja, Lauri Kutt, Kimmo Kauhaniemi, Ivo Palu   +5 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Effect of panel method codes in estimating the time-domain responses of floating wind turbines

Brodogradnja
This study investigates the impact of frequency-domain hydrodynamic outputs from several panel method codes on estimating time domain responses of floating wind turbines. The tools under examination are WAMIT and three open-source codes (HAMS, NEMOH, and
Muhammed Ucar, Mohamad Hmedi, Emre Uzunoglu, Elif Oguz   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source