Results 81 to 90 of about 5,380,901 (293)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Multi-degree-of-freedom hydrodynamic performance study of finned floats

Zhongguo Jianchuan Yanjiu
ObjectiveTo optimize the energy capture efficiency of a rocker-type wave energy converter, the effects of the platform pillar wave diversion scheme and shape of finned floats on energy capture are studied.MethodsFirst, a hydrodynamic model of float ...
Wei ZHANG, Zengyuan REN, Yifan XU, Biao ZHANG, Detang LI, Hao LI   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Time domain and frequency domain numerical calculation methods for transient noise of cruise ship cabins

Zhongguo Jianchuan Yanjiu
ObjectiveThe purpose of this paper is to explore an efficient and accurate numerical calculation method for cabin transient noise under transient excitation.
Yingying ZUO, Deqing YANG, Jian XIAO
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Online Battery Resistance Estimation Algorithm With Down-Sampling and Preprocessing Filter in Embedded DC-DC Power Converters

IEEE Open Journal of Power Electronics
The safety and reliability of lithium-ion batteries have become increasingly critical due to the rising risk of fire incidents in electric vehicles and energy storage systems.
Mina Kim, Seung-Jong Kim, Jia Hong, Hwa-Pyeong Park   +3 more
doaj   +1 more source

Seakeeping analysis of two ships advancing parallel for underway replenishment

Zhongguo Jianchuan Yanjiu, 2017
Due to the wave and hydrodynamic interaction between two ships advancing parallel on the ocean, their six-degrees-of-freedom motions are much more complex during replenishment. The seakeeping performance of two vessels is analyzed with AQWA. On the basis
ZHENG Pingyu, LI Peng, LIU Jingxi, YE Hengkui   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source