Results 71 to 80 of about 1,948,990 (300)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Measurement of the space-time interval between two events using the retarded and advanced times of each event with respect to a time-like world-line

, 2007
Several recent studies have been devoted to investigating the limitations that ordinary quantum mechanics and/or quantum gravity might impose on the measurability of space-time observables.
B.S. DeWitt, C.A. Mead, D. Amati, D.J. Gross, D.V. Ahluwalia, E.P. Wigner, F. Dowker, G. Veneziano, Giovanni Amelino-Camelia, H. Salecker, J. Stachel, J. Stachel, John Stachel, L.D. Landau, L.J. Garay, M.P. Bronstein, N. Bohr, N. Bohr, P.G. Bergmann, R.J. Adler, S. Doplicher, S. Lloyd, T. Padmanabhan, Y.J. Ng   +23 more
core   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Deccoherent Histories and Measurement of Temporal Correlation Functions for Leggett-Garg Inequalities

, 2016
We consider two protocols for the measurement of the temporal correlation functions of a dichotomic variable Q appearing in Leggett-Garg type inequalities.
Halliwell, J. J.
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Measurement of Time-Dependent CP-Violating Parameters in B0 -> K0S K0S decays

, 2007
We report a measurement of the CP-violating parameters in B0->K0S K0S decays based on a data sample of 657 million BBbar pairs collected at the Y(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+e- collider.
A. Bondar, A. Bozek, A. Chen, A. Drutskoy, A. Ishikawa, A. J. Schwartz, A. Kuzmin, A. Limosani, A. M. Bakich, A. Somov, A. Zupanc, B. G. Cheon, B. Golob, B. Shwartz, C. C. Kuo, C. H. Wang, C. P. Shen, C. Schwanda, C. W. Park, D. H. Kah, D. Heffernan, D. Liventsev, E. Barberio, E. Nakano, E. Won, F. Mandl, F. Takasaki, G. N. Taylor, G. Pakhlova, G. R. Moloney, G. Varner, H. Aihara, H. Ha, H. Ishino, H. J. Hyun, H. J. Kim, H. Kaji, H. Kakuno, H. Kawai, H. Kichimi, H. Miyata, H. Nakazawa, H. O. Kim, H. Ozaki, H. Park, H. Sahoo, H. Shibuya, H. Tajima, I. Adachi, I. Bedny, I. Tikhomirov, I.-S. Cho, J. B. Singh, J. Dalseno, J. H. Kang, J. Haba, J. Lee, J. S. Lee, J.-G. Shiu, K. Belous, K. Hara, K. Hayasaka, K. Inami, K. Kinoshita, K. Miyabayashi, K. S. Park, K. Sumisawa, K. Trabelsi, K. Ueno, K. Vervink, K.-F. Chen, L. E. Piilonen, M. Bračko, M. Dash, M. E. Sevior, M. Hazumi, M. Iwasaki, M. J. Lee, M. Nakao, M. Shapkin, M. Starič, M. Tanaka, N. Gabyshev, N. Katayama, N. Tamura, O. Nitoh, O. Schneider, O. Tajima, O. Zyukova, P. Chang, P. Križan, P. Krokovny, P. Pakhlov, P. Wang, R. Chistov, R. Itoh, R. Kumar, R. Mizuk, R. Pestotnik, R. Seidl, S. E. Lee, S. Eidelman, S. Korpar, S. L. Olsen, S. McOnie, S. Nishida, S. Ogawa, S. Okuno, S. Stanič, S. Uehara, S. Uno, S.-W. Lin, T. Aushev, T. E. Browder, T. Hara, T. Iijima, T. Kawasaki, T. Lesiak, T. Medvedeva, T. Nozaki, T. Ohshima, T. Sumiyoshi, T. Tsuboyama, T. Uglov, U. Bitenc, V. Balagura, W. Mitaroff, W. T. Chen, X. L. Wang, Y. B. Hsiung, Y. Chao, Y. Choi, Y. Hoshi, Y. Iwasaki, Y. J. Kim, Y. Miyazaki, Y. Nakahama, Y. Sakai, Y. Teramoto, Y. Unno, Y. Ushiroda, Y. Watanabe, Y. Yamashita, Y. Yusa, Y.-J. Kwon, Z. Natkaniec, Z. P. Zhang   +146 more
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Low cost automated precise time measurement system [PDF]

The Aerospace Guidance and Metrology Center (AGMC) has the responsibility for the dissemination of Precise Time and Time Interval (PTTI) to Air Force timing systems requiring microsecond time. In order to maintain traceability to the USNO Master Clock in
Alpert, A., Liposchak, P.
core   +1 more source