Results 91 to 100 of about 640,490 (255)

Monarchy as private property government. A chiefly methodological critique

Zagadnienia Filozoficzne w Nauce
Hans-Hermann Hoppe famously argued that monarchy is superior to democracy insofar as property rights protection is concerned. The present paper calls this claim into question, with much of the heavy lifting being done by methodological ponderings.
Norbert Slenzok
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Behavioral effects in time preference for losses depend on direction of delay discounting and level of data analysis

Judgment and Decision Making
While most research on time preference has focused on gains, understanding time preference for losses is also crucial in practice. Some studies have shown that people prefer to bear a loss earlier rather than later, suggesting negative delay discounting.
Zhuoyi Fan, Xuhui Zhang, Yue Shen, Junyi Dai   +3 more
doaj   +1 more source

A Brief Defense of Mises's Conception of Time Preference and His Pure Time Preference Theory of Interest

Quarterly Journal of Austrian Economics, 2018
In his recent book, _Money, Interest and the Structure of Production_ (Machaj, 2017), Mateusz Machaj advances two significant criticisms of Mises’s theory of time preference and his pure time preference theory of interest (PTPT).
G.P. Manish
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Effects of Risk and Time Preferences on Diet Quality: Empirical Evidence from Rural Madagascar

Foods
Malnutrition is a major concern in Madagascar. Eating a wide variety of nutritious food is necessary because Malagasy diets heavily rely on rice consumption.
Sakiko Shiratori, Mudduwa Gamaethige Dilini Abeysekara, Ryosuke Ozaki, Jules Rafalimanantsoa, Britney Havannah Rasolonirina Andrianjanaka   +4 more
doaj   +1 more source

Indecisiveness on risk preference and time preference choices. Does financial literacy matter?

Cogent Psychology, 2019
The aim of this study is to investigate the relationship between financial literacy and decisiveness in making risk preference and time preference choices by university students.
Calvin Mudzingiri, John W. Muteba Mwamba, Jacobus Nicolaas Keyser, Alex Bara   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source