Results 81 to 90 of about 640,490 (255)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Discounting Practices in Cost-Effectiveness Analyses in Dentistry: A Systematic Review of Studies Published After 2020

ClinicoEconomics and Outcomes Research
Ramona Maruster,1 Michael M Bornstein,1 Pedram Sendi1,2 1Department of Oral Health & Medicine, University Center for Dental Medicine Basel, Basel, Switzerland; 2Division of Clinical Epidemiology, Department of Clinical Research, Basel University ...
Maruster R, Bornstein MM, Sendi P
doaj  

Evaluation Scale or Output Format: The Attentional Mechanism Underpinning Time Preference Reversal. [PDF]

Front Psychol, 2022
Zhou YB, Li Q, Li QY, Liu HZ.
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Perceived temporal distortions may explain the effect of precarity on intertemporal choices

Frontiers in Psychology
Existing research on how environmental volatility affect preferences suggests that preference for delayed rewards reduces in the presence of adverse shocks.
Arjun Mitra, Nisheeth Srivastava, Nisheeth Srivastava   +2 more
doaj   +1 more source

Overweight/Obesity and Time Preference: Evidence from a Survey among Adults in the UK. [PDF]

Obes Facts, 2022
Touray MML, Cohen DR, Williams SRP, Alam MF, Groves S, Longo M, Gage H.   +6 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Survey of time preference, delay discounting models

Judgment and Decision Making, 2013
The paper surveys over twenty models of delay discounting (also known as temporal discounting, time preference, time discounting), that psychologists and economists have put forward to explain the way people actually trade off time and money.
John R. Doyle
doaj   +1 more source

Time Preference for Immediate Gratification: Associations With Low Medication Adherence and Uncontrolled Blood Pressure. [PDF]

Am J Hypertens, 2022
Krousel-Wood M, Peacock E, Bradford WD, Mohundro B, Craig LS, O'Connell S, Bazzano L, Shi L, Ford M.   +8 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source