Results 91 to 100 of about 7,974,129 (270)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Using modern time series analysis techniques to predict ENSO events from the SOI time series [PDF]
Nonlinear Processes in Geophysics, 2002 We analyze the monthly 1866-2000 Southern Oscillation Index (SOI) data to determine: 1) whether the SOI data are sufficiently noise-free that useful predictions can be made from them, and 2) in particular, whether future ENSO events can be predicted
J. I. Salisbury, M. Wimbush
doaj
Information system for operation analysis of time series [PDF]
, 2018 This work is devoted to modern information technology of operational analysis of time series. The main purpose of data operational analysis is replenishment, data blurring, smoothing and forecasting of time series, obtaining conclusions about ...
Brusko, W. +4 more
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Time series analysis and forecasting with ECOTOOL.
PLoS ONE, 2019 This paper presents ECOTOOL, a new free MATLAB toolbox that embodies several routines for identification, validation and forecasting of dynamic models.
Diego J Pedregal
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Multiscale entropy analysis of electroseismic time series [PDF]
Natural Hazards and Earth System Sciences, 2008 In this work we use the multiscale entropy method to analyse the variability of geo-electric time series monitored in two sites located in Mexico. In our analysis we consider a period of time from January 1995 to December 1995.
L. Guzmán-Vargas +2 more
doaj
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source