Results 81 to 90 of about 2,530,237 (313)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

MultiCenter Interrupted Time Series Analysis: Incorporating Within and Between-Center Heterogeneity

open access: yesClinical Epidemiology, 2020
Joycelyne E Ewusie,1,2 Lehana Thabane,1 Joseph Beyene,1 Sharon E Straus,3 Jemila S Hamid1,2,4 1Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada; 2School of Epidemiology and Public Health ...
Ewusie JE   +4 more
doaj  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Time-varying spectral analysis in neurophysiological time series using Hilbert wavelet pairs [PDF]

open access: yes, 2005
An analytic wavelet transform, based on Hilbert wavelet pairs, is applied to bivariate time-varying spectral estimation for neurophysiological time series.
Whitcher, Brandon   +2 more
core   +1 more source

Contextual Analysis of Financial Time Series

open access: yesMathematics
The evaluation of the financial state of small and medium-sized companies is a pressing issue today. This article introduces a novel method to evaluate a company’s financial state, implemented as a module within a decision support system.
Nadezhda Yarushkina   +2 more
doaj   +1 more source

Chaotic Time Series Analysis [PDF]

open access: yesMathematical Problems in Engineering, 2010
Chaotic dynamical systems are ubiquitous in nature and most of them does not have an explicit dynamical equation and can be only understood through the available time series. We here briefly review the basic concepts of time series and its analytic tools, such as dimension, Lyapunov exponent, Hilbert transform, and attractor reconstruction.
openaire   +2 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Heuristic Analysis of Time Series Internal Structure [PDF]

open access: yes
A method of analysis of Time Series Internal Structures based on Singular Spectrum Analysis is discussed. It has been shown that in the case when the Time Series contains deterministic additive components rank of the trajectory matrices equal to number ...
Alexander Milnikov, Cihan Mert
core   +1 more source

TATS: toolbox for time series data augmentation [PDF]

open access: yesPeerJ Computer Science
Augmenting time series data plays a crucial role in enhancing the generalization of classification models, especially in scenarios where labeled datasets are limited.
Dawid Warchoł, Mariusz Oszust
doaj   +2 more sources

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