Results 91 to 100 of about 1,465,984 (298)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Current driven switching of magnetic layers

, 2000
The switching of magnetic layers is studied under the action of a spin current in a ferromagnetic metal/non-magnetic metal/ferromagnetic metal spin valve.
A. I. Akhieser, A.G. Gurevich, B. Heinrich, C. Heide, C. Heide, C. Heide, C. Heide, C. Heide, E.B. Myers, J.A. Katine, J.C. Slonczewski, J.C. Slonczewski, J.C. Slonczewski, J.J. Krebs, J.Z. Sun, J.Z. Sun, L. Berger, M. Tsoi, N.F. Schwabe, P. E. Zilberman, P. Grünberg, P.C. van Son, R. J. Elliott, S. Chikazumi, S.J.C.H. Theeuwen, T. Valet   +25 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A Time Domain ISFET With Dynamic Reference Switching

IET Circuits, Devices and Systems
This paper presents an enhanced linear pulse-frequency modulator (LPFM) ion-sensitive field-effect transistor (ISFET) architecture with a programmable dynamic range for pH detection. The circuit encodes the pH signal into the frequency domain.
Jose Cortes Guzman, Pablo G. Ledesma Lopez, Andreas Tsiamis, David R. S. Cummings, Srinjoy Mitra   +4 more
doaj   +1 more source

State-Dependent Switching Control with Dwell Time Regulation for Three-Phase VSCs Based on 4D Switching Model

Energies
This paper proposes a novel modeling and control strategy for three-phase voltage source converters (VSCs) based on a switched system framework. A four-dimensional (4D) switched model and state-dependent switching control strategy with dwell time ...
Xin Guo, Hongyi Qi, Hongbo Cao, Celso Grebogi, Shangbin Jiao   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Performance Enhancement for Full-Duplex Relaying with Time-Switching-Based SWIPT in Wireless Sensors Networks. [PDF]

Sensors (Basel), 2021
Tin PT, Nguyen TN, Tran DH, Voznak M, Phan VD, Chatzinotas S.   +5 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Stochastic switching time constant and instability in nanomagnets

Communications Materials
The Arrhenius law governs thermally-activated phenomena with a pre-exponential factor, the attempt time τ 0, which defines the time constant of stochastic process.
Shun Kanai, Keisuke Hayakawa, Mehrdad Elyasi, Keito Kobayashi, Junta Igarashi, Butsurin Jinnai, William A. Borders, Gerrit E. W. Bauer, Hideo Ohno, Shunsuke Fukami   +9 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source