Results 101 to 110 of about 16,788,032 (264)
, 1990 This second edition includes a focus on the social trends and service implications for families with ...
Community Trends Working Group
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Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
OECD Energy Demand: Modelling Underlying Energy Demand Trends using the Structural Time Series Model [PDF]
Aggregate energy demand functions for 17 OECD countries are estimated with data for 1960-2003 using the Structural Time Series Model (STSM) thus allowing for a stochastic Underlying Energy Demand Trend (UEDT).
Arqam Al-Rabbaie, Lester C. Hunt
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Infection and Drug Resistance, 2016 Michele H Potashman,1 Michael Stokes,2 Jieruo Liu,2 Robin Lawrence,1 Linda Harris1 1Global Health Outcomes, Merck & Co, Inc., Kenilworth, NJ, USA; 2Evidera, Lexington, MA, USA Purpose: Skin infections, particularly those caused by resistant ...
Potashman MH +4 more
doaj
Application of the age-period-cohort model in tuberculosis
Frontiers in Public HealthUp to now, tuberculosis (TB) remains a global public health problem, posing a serious threat to human health. Traditional methods for analyzing time-varying trends, such as age and period, tend to ignore the poor impact of birth cohorts, which is an ...
Dan Luo +10 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Influenza-attribuable mortality among the elderly in Switzerland
Swiss Medical Weekly, 2006 MWG Brinkhof, A Birrer, R Hagman
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Stochastic Trends and Economic Fluctuations [PDF]
Recent developments in macroeconomic theory emphasize that transient economic fluctuations can arise as responses to changes in long run factors -- in particular, technological improvements -- rather than short run factors.
Robert G. King +3 more
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