Results 101 to 110 of about 19,050,909 (270)

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

How have employees fared? Recent UK trends [PDF]

An analysis of trends over the past decade in earnings, job growth, employment security and working time experienced by UK employees.DTI; EMAR; Great Britain; UK; employment relations research series; Labour Force Survey; labour market; employees ...
Fitzner, Grant
core  

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

OECD Energy Demand: Modelling Underlying Energy Demand Trends using the Structural Time Series Model [PDF]

Aggregate energy demand functions for 17 OECD countries are estimated with data for 1960-2003 using the Structural Time Series Model (STSM) thus allowing for a stochastic Underlying Energy Demand Trend (UEDT).
Arqam Al-Rabbaie, Lester C. Hunt
core  

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Temporal analysis of animal bite incidents in a tertiary care hospital in Western Maharashtra [PDF]

Al Ameen Journal of Medical Sciences
Background: Rabies is a fatal disease with no cure but 100% preventable and effective vaccines are available. Time trends in epidemiological factors related to exposure to biting animal, management & adherence to vaccination have poorly studied.
Sudesh Gandham, Atul A. Jagtap
doaj  

Changes over time in the genetic parameters of milk production and functional traits in a Holstein population

Cogent Food & Agriculture
Changes over time in the genetic parameters for milk yield (MY), fat yield (FY), protein yield (PY), fat content (FC), protein content (PC), longevity (LONG), somatic cell score (SCS), calving interval (CI) and age at first calving (AFC) were estimated ...
Juana Lucia Chuma-Alvarez, Hugo Horacio Montaldo, Felipe de Jesús Ruiz-López, Adriana García-Ruiz, Carlos Lizana, Mario Eduardo Olivares   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Evolution of Home Mechanical Ventilation in Sweden Over 27 YearsTake-home Points

CHEST Pulmonary
Background: Home mechanical ventilation (HMV), noninvasive ventilation and invasive ventilation outside a hospital setting, is a key treatment to improve outcomes in chronic hypoventilation.
Andreas Palm, MD, PhD, Ludger Grote, MD, PhD, Jonas Einarsson, MD, Daniel Hansson, MD, Mirjam Ljunggren, MD, PhD, Josefin Sundh, MD, PhD, Magnus Ekström, MD, PhD   +6 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source