Results 71 to 80 of about 16,788,032 (264)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Dental anxiety and dental attendance among 25-year-olds in Norway: time trends from 1997 to 2007

BMC Oral Health, 2011
Background So far, there are few studies considering the development of dental anxiety and dental attendance patterns across time in the general population of Norwegian adults.
Skaret Erik, Åstrøm Anne N, Haugejorden Ola   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Linear trends in seasonal vegetation time series and the modifiable temporal unit problem [PDF]

, 2012
Time series of vegetation indices (VI) derived from satellite imagery provide a consistent monitoring system for terrestrial plant productivity. They enable detection and quantification of gradual changes within the time frame covered, which are of ...
de Jong, R., S. de Bruin, Bruin, S., de, de Bruin, S, de Bruin, S., de Jong, Rogier, Jong, R., de, R. de Jong   +7 more
core   +2 more sources

Population Trends of New Prescriptions for Antihyperglycemics and Antihypertensives Between 2014 and 2022

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background In the wake of pandemic‐related health decline and health care disruptions, there are concerns that previous gains for cardiovascular risk factors may have stalled or reversed.
Amy Y. X. Yu, Peter C. Austin, Cynthia A. Jackevicius, Anna Chu, Jessalyn K. Holodinsky, Michael D. Hill, Noreen Kamal, Mukesh Kumar, Douglas S. Lee, Manav V. Vyas, Raed A. Joundi, Nadia A. Khan, Moira K. Kapral, Candace D. McNaughton   +13 more
doaj   +1 more source

Decreasing Risk of Fatal Subarachnoid Hemorrhage and Other Epidemiological Trends in the Era of Coiling Implementation in Australia

Frontiers in Neurology, 2017
Background and purposeSubarachnoid hemorrhage (SAH) is associated with a high risk of mortality and disability in survivors. We examined the epidemiology and burden of SAH in our population during a time services were re-organized to facilitate access to
John Mark Worthington, John Mark Worthington, John Mark Worthington, Chris Goumas, Bin Jalaludin, Bin Jalaludin, Melina Gattellari   +6 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Prevalence and Incidence Rates of Atrial Fibrillation in Denmark 2004–2018

Clinical Epidemiology, 2022
Emilie R Hegelund,1,2 Lars J Kjerpeseth,3 Laust H Mortensen,1,2 Jannicke Igland,4 Trygve Berge,5 Mariam Anjum,3,5 Grethe S Tell,4 Inger Ariansen3 1Methodology and Analysis, Statistics Denmark, Copenhagen, Denmark; 2Department of Public Health, University
Hegelund ER, Kjerpeseth LJ, Mortensen LH, Igland J, Berge T, Anjum M, Tell GS, Ariansen I   +7 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source