Results 71 to 80 of about 19,050,909 (270)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Mental Health Trends in the United Kingdom, 1991–2025: A Time-Series Analysis

European Journal of Mental Health
Introduction: There is ongoing debate regarding increasing trends in mental health symptoms, particularly among younger people. Aim: This study examined mental health trends in the United Kingdom from 1991 to 2025.
Gabriele Prati
doaj   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Under the Clouds of War

, 1972
Consists of film clips of World War II events, including Mussolini\u27s invasion of Ethiopia and Hitler\u27s march into Austria.
Time-Life Video
core  

Temporal studies of cancer occurrence and applications of the age-period-cohort method to trends in Europe [PDF]

This thesis examines the utility of temporal studies of cancer in practice, particularly from the perspective of analyses of the three underlying time components, age, period of event and birth cohort.
Bray, Freddie Ian
core   +1 more source

Age‐Specific Trends in Carcinoma Incidence Among Adolescents and Young Adults in the United States, 1975–2021

Cancer Medicine
Introduction The incidence of carcinomas among adolescents and young adults (AYAs; ages 15–39) is rising. However, most research treats AYAs as a single group, potentially obscuring important age‐ and sex‐specific trends.
Adrian D. Aguilar, Satya Batna, Rebecca D. Kehm   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Time trends in study attributes.

, 2019
Time trends in study attributes.
Samantha Y. Rowe (6786341), Alexander K. Rowe (4898926), Kathleen A. Holloway (6786344), John Chalker (3437300), Dennis Ross-Degnan (386696), David H. Peters (347388)   +5 more
core   +1 more source

Global, regional, and national time trends in falls and their predictions: an age-period-cohort analysis of the Global Burden of Disease Study 2021

Frontiers in Public Health
BackgroundFalls are a global public health issue with a heavy disease and socioeconomic burden, with an increasing number of risky people. The aim of this study is to explore the global disease burden of falls and to provide a scientific basis for the ...
Huan Jiang, Ning Sun, Huiqi Yang, Ye Li, Ye Li, Lihong Jiang, Huicui Zhao, Yi Zeng, Chengyang Sun, Chun Xu, Yongqiang Lai, Jia Meng   +11 more
doaj   +1 more source