Results 41 to 50 of about 560,525 (264)

Robust Optimization for Electric Vehicle Routing Problem Considering Time Windows Under Energy Consumption Uncertainty

open access: yesApplied Sciences
Compared to fossil fuel-based internal combustion vehicles, electric vehicles with lower local pollution and noise are becoming more and more popular in urban logistic distribution.
Dan Wang, Weibo Zheng, Hong Zhou
doaj   +1 more source

Heterogeneous Multitype Fleet Green Vehicle Path Planning of Automated Guided Vehicle with Time Windows in Flexible Manufacturing System

open access: yesMachines, 2022
In this study, we present and discuss a variant of the classical vehicle routing problem (VRP), namely the heterogeneous multitype fleet green automated guided vehicle (AGV) routing problem with time windows (HFGVRPTW) applied in the workshops of ...
Jia Gao   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Simulated annealing (SA) to vehicle routing problems with soft time windows

open access: yesKKU Engineering Journal, 2014
The researcher has applied and develops the meta-heuristics method to solve Vehicle Routing Problems with Soft Time Windows (VRPSTW). For this case there was only one depot, multi customers which each generally sparse either or demand was different ...
Suphan Sodsoon   +2 more
doaj  

Accurate Real-Time Windowed Time Warping. [PDF]

open access: yes, 2010
[TODO] Add abstract here.
Robert Macrae, Simon Dixon
openaire   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Bi-Objective Optimization for Sustainable Logistics in the Closed-Loop Inventory Routing Problem

open access: yesEngineering Proceedings
This study proposes a bi-objective optimization model for the inventory routing problem with pickup and delivery (IRP–PD) in a closed-loop supply chain, addressing the growing demand for sustainable logistics solutions. The model simultaneously minimizes
Chaima Zormati   +3 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

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