Results 51 to 60 of about 16,183,947 (297)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Production, 2006 Este trabalho estuda a implementação da metaheurística scatter search (SS) em um problema real de roteirização de veículos com frota heterogênea, janelas de tempo e entregas fracionadas.
Patrícia Prado Belfiore +1 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Bi-Objective Optimization for Sustainable Logistics in the Closed-Loop Inventory Routing Problem
Engineering ProceedingsThis study proposes a bi-objective optimization model for the inventory routing problem with pickup and delivery (IRP–PD) in a closed-loop supply chain, addressing the growing demand for sustainable logistics solutions. The model simultaneously minimizes
Chaima Zormati +3 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Solving a multi-depot vehicle routing problem with time windows and fuzzy demands using metaheuristic algorithms in home health care services [PDF]
تصمیم گیری و تحقیق در عملیات, 2018 Todays, meeting the healthcare needs of patients at home has many benefits. By providing regular and timely healthcare servicing, in addition to reducing costs, the patient's recovery process also speeds up.
Masoud Rabbani +3 more
doaj +1 more source
Mathematics, 2023 We propose a vehicle routing problem with time windows (VRPTW) with compatibility-matching constraints and total completion time as the objective function, with applications in home healthcare routing and scheduling.
Payakorn Saksuriya, Chulin Likasiri
doaj +1 more source
Time window analysis and sorting [PDF]
Cytometry, 1991 AbstractFlow cytometric hardware and procedures were developed to continuously analyse and to sort a particular time window in a kinetic response. The technique uses balanced air pressure to drive a stimulus‐bead mixture from a vial to a t‐junction where it mixes passively with cells.
openaire +2 more sources
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Algorithms, 2020 The Vehicle Routing Problem with Time Windows (VRPTW) is an NP-Hard optimization problem which has been intensively studied by researchers due to its applications in real-life cases in the distribution and logistics sector.
Grigorios D. Konstantakopoulos +4 more
doaj +1 more source