Results 61 to 70 of about 2,034,197 (287)
A Computational Study of Genetic Crossover Operators for Multi-Objective Vehicle Routing Problem with Soft Time Windows [PDF]
, 2008 The article describes an investigation of the effectiveness of genetic algorithms for multi-objective combinatorial optimization (MOCO) by presenting an application for the vehicle routing problem with soft time windows.
Geiger, Martin Josef
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Applied SciencesThe use of electric vehicles in urban transportation is increasing daily due to their energy efficiency and environmental friendliness. In last-mile logistics, route optimization must consider charging station locations while balancing operational costs ...
Yasin Ünal +3 more
doaj +1 more source
Tackling Dynamic Vehicle Routing Problem with Time Windows by means of Ant Colony System
, 2017 The Dynamic Vehicle Routing Problem with Time Windows (DVRPTW) is an extension of the well-known Vehicle Routing Problem (VRP), which takes into account the dynamic nature of the problem.
Breaban, Mihaela +2 more
core +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Combinatorial approach to detection of fixed points, periodic orbits, and symbolic dynamics
, 2017 We present a combinatorial approach to rigorously show the existence of fixed points, periodic orbits, and symbolic dynamics in discrete-time dynamical systems, as well as to find numerical approximations of such objects.
Gidea, Marian, Shmalo, Yitzchak
core +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Impact maturity times and citation time windows: The 2-year maximum journal impact factor
, 2013 Journal metrics are employed for the assessment of scientific scholar journals from a general bibliometric perspective. In this context, the Thomson Reuters journal impact factors (JIF) are the citation-based indicators most used.
Dorta-Gonzalez, Maria Isabel +1 more
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source