Results 61 to 70 of about 2,029,326 (338)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Optimized Travel Itineraries: Combining Mandatory Visits and Personalized Activities

Algorithms
Tourism refers to the activity of traveling for pleasure, recreation, or leisure purposes. It encompasses a wide range of activities and experiences, from sightseeing to cultural exploration.
Parida Jewpanya, Pinit Nuangpirom, Siwasit Pitjamit, Warisa Nakkiew   +3 more
doaj   +1 more source

Loading Method and Routing Optimizations of Fresh Products on Multi-Temperature Joint Distribution With Limited Flexible-Size Compartments

IEEE Access, 2023
The value of fresh agricultural products decreases over time. For customers, timely delivery of products is essential and both freshness and quality are their top priorities.
Nana Zhang, Qi An, Xuping Wang
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Examination of time series through randomly broken windows [PDF]

The effect of irregular interruption of data collection (the breaking of the window function) on the spectrum determination of a time series is investigated.
Sturrock, P. A.
core   +4 more sources

Time Window Characteristics in a Heuristic Algorithm for a Full-Truck Vehicle Routing Heuristic Algorithm in An Intermodal Context

Jurnal Optimasi Sistem Industri
Intermodal container terminals handle both the pickup and delivery of containers to and from customers, with these transport activities and terminal handling comprising a significant portion of intermodal transport costs.
Wisute Ongcunaruk, Pornthipa Ongkunaruk, Gerrit Janssens   +2 more
doaj   +1 more source

Tackling Dynamic Vehicle Routing Problem with Time Windows by means of Ant Colony System

, 2017
The Dynamic Vehicle Routing Problem with Time Windows (DVRPTW) is an extension of the well-known Vehicle Routing Problem (VRP), which takes into account the dynamic nature of the problem.
Breaban, Mihaela, Necula, Raluca, Raschip, Madalina   +2 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Electric Vehicle Routing with Time Windows and Charging Stations from the Perspective of Customer Satisfaction

Applied Sciences
The use of electric vehicles in urban transportation is increasing daily due to their energy efficiency and environmental friendliness. In last-mile logistics, route optimization must consider charging station locations while balancing operational costs ...
Yasin Ünal, İnci Sarıçiçek, Sinem Bozkurt Keser, Ahmet Yazıcı   +3 more
doaj   +1 more source