Results 81 to 90 of about 2,029,326 (338)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Effective collective barrier for magnetic relaxation in frozen ferrofluids

, 2003
Magnetic relaxation and frequency response were measured in frozen ferrimagnetic colloids of different concentrations. A crossover from reversible to irreversible behavior is observed for concentrated colloids.
Blatter, Denisov, Dormann, Eberbeck, Garanin, Griessen, Iglesias, Jonsson, Jonsson, Lottis, Luo, Maley, Mamiya, Mørup, Néel, Pazmandi, Prozorov, Prozorov, Prozorov, Ruslan Prozorov, Shafi, Stoner, Suslick, Suslick, Tanya Prozorov, Templeton, van Lierop, Yeshurun, Zeldov, Zhang   +29 more
core   +1 more source

Accurate Real-Time Windowed Time Warping.

, 2010
[TODO] Add abstract here.
Macrae, Robert, Dixon, Simon
openaire   +1 more source

Multi Depot Traveling Repairmen Problem with Time Windows: A Mathematical Model and a Metaheuristic [PDF]

, 2021
Gözde Önder Uzun, Berna Dengiz, İmdat Kara, Oya Ekin Karaşan   +3 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

On distribution of number of trades in different time windows in the stock market

, 2004
Properties of distributions of the number of trades in different intraday time intervals for five stocks traded in MICEX are studied. The dependence of the mean number of trades on the capital turnover is analyzed.
A.V. Leonidov, Arneodo, Bacry, Bialas, Bonanno, Bouchaud, Brax, Buican, De Wolf, Dokshitzer, Dracorogna, Dremin, Dremin, Dremin, Dremin, Dremin, Dremin, Dremin, Dremin, Giovannini, I.M. Dremin, Kittel, Leonidov, Matia, Muzy, Ochs, Ochs, Plerou, Voit   +28 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Optimizing Vehicle Routing for Simultaneous Delivery and Pick-Up Considering Reusable Transporting Containers: Case of Convenience Stores

Applied Sciences, 2020
Previous studies have proposed various frameworks and algorithms to optimize routes to reduce total transportation cost, which accounts for over 29.4% of overall logistics costs.
Intaek Gong, Kyungho Lee, Jaewon Kim, Yunhong Min, KwangSup Shin   +4 more
doaj   +1 more source

Scale free networks of earthquakes and aftershocks

, 2003
We propose a new metric to quantify the correlation between any two earthquakes. The metric consists of a product involving the time interval and spatial distance between two events, as well as the magnitude of the first one.
A. Helmstetter, A. Wagner, B. Gutenberg, C. Frohlich, C. H. Scholz, D. P. Hill, D. Stauffer, D. Turcotte, F. Omori, G. M. Molchan, J. Gardner, L. Knopoff, L. Knopoff, M. Faloutsos, Marco Baiesi, Maya Paczuski, P. Bak, P. Bak, T. Hirata, T. Utsu, V. Keilis-Borok, Y. Y. Kagan   +21 more
core   +1 more source

Time Windowed Data Structures for Graphs

Journal of Graph Algorithms and Applications, 2019
We present data structures that can answer time windowed queries for a set of timestamped events in a relational event graph. We study the relational event graph as input to solve (a) time windowed decision problems for monotone graph properties, such as disconnectedness and bipartiteness, and (b) time windowed reporting problems such as reporting the ...
Chanchary, Farah, Maheshwari, Anil
openaire   +2 more sources