Results 41 to 50 of about 1,231,330 (253)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Efficient online monitoring of web-service SLAs [PDF]

, 2008
If an organization depends on the service quality provided by another organization it often enters into a bilateral service level agreement (SLA), which mitigates outsourcing risks by associating penalty payments with poor service quality.
Skene, J, Franco Raimondi, Raimondi, F, Wolfgang Emmerich, James Skene, Emmerich, W   +5 more
core   +1 more source

Effect of gonadorelin dose and an additional gonadorelin treatment 2 days after the initiation of Resynch-25 on ovarian dynamics and fertility of lactating Holstein cows

Journal of Dairy Science
: Our objective was to improve ovulatory response at the initiation of the Resynch-25 protocol by (1) increasing the dose of GnRH from 100 µg to 200 µg; and (2) giving a second GnRH treatment 56 h after the initiation of the protocol.
Iago M.R. Leão, Carlos E.C. Consentini, Marcelo S. El Azzi, Everaldo Anta-Galván, Teresita Valdés-Arciniega, Lucas Oliveira e Silva, Roberto Sartori, João Paulo N. Martins   +7 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Verification of Timed Automata with Deadlines in Uppaal [PDF]

, 2008
Timed Automata with Deadlines (TAD) is a notation to model concurrent real-time systems that has a number of advantages over mainstream Timed Automata (TA). The semantics of deadlines and synchronisation rule out the most common form of timelocks, making
Gomez, Rodolfo
core  

Effect of 200 µg of gonadorelin at the first gonadotropin-releasing hormone of the Resynch-25 on ovarian dynamics and fertility in lactating Holstein cows

Journal of Dairy Science
: Our objective was to determine the effect of a 200-µg dose of GnRH 25 d after previous artificial insemination (AI) in a Resynch-25 resynchronization program on ovulatory response, circulating progesterone (P4) concentrations before and after treatment,
Iago M.R. Leão, Marcelo S. El Azzi, Everaldo Anta-Galván, Teresita Valdés-Arciniega, João Paulo N. Martins   +4 more
doaj   +1 more source

Effect of nerve growth factor-β administered at insemination for lactating Holstein dairy cows bred after timed-artificial insemination protocol

Journal of Dairy Science, 2022
: The objectives of this study were to determine the effects of nerve growth factor-β (NGF), purified from bulls' seminal plasma and administered at the time of artificial insemination (AI), on progesterone post-AI, interferon-stimulated genes (ISG), and
A.M. Hubner, I.F. Canisso, P.M. Peixoto, W.M. Coelho, Jr., L.L. Cunha, L. Ribeiro, S. Crump, F.S. Lima   +7 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

When Implementing the Presynch-11/Ovsynch Reproductive Management Program, the Fertility of Lactating Dairy Cows Improved When They Received Timed Artificial Insemination Compared with the Inclusion of Estrus Detection

Animals
Artificial insemination 12 h following observed standing estrus is a standard estimate of the fertility levels of cattle. The main objective of this study was to determine if controlling ovarian development with a fertility program could alter the ...
Jaimie Marie Strickland, João Paulo Nascimento Martins, Lou Neuder, James R. Pursley   +3 more
doaj   +1 more source

Effect of delayed timing of artificial insemination with sex-sorted semen on pregnancy per artificial insemination in synchronized dairy heifers managed in a seasonal-calving pasture-based system

JDS Communications, 2023
The objective of this study was to evaluate the timing of artificial insemination (AI) with frozen-thawed sex-sorted semen on pregnancy per AI (P/AI) in dairy heifers.
S.G. Moore, A.D. Crowe, F. Randi, S.T. Butler   +3 more
doaj   +1 more source