Results 61 to 70 of about 11,364 (306)

Economic benefit in repeat breeder cows using intrauterine infusion of penicillin and estrus synchronization followed by timed artificial insemination

Journal of Advanced Veterinary and Animal Research, 2018
Objective: Until recently, management of repeat breeding in cattle remains a major problem to dairy farmers. This study was carried out to improve the fertility in cows, those did not conceive after three or more consecutive services.
Abul Khair, Md. Asaduzzaman, Zinat Sultana, Anup Kumar Taluker, Ziban Chandra Das, Md. Golam Shahi Alam, Mohammed Shamsuddin   +6 more
doaj   +1 more source

Comparative Study of Pregnancy Rate of Dairy Cows Inseminated with Fresh or Frozen-Thawed Semen

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2020
The aim of this study was to investigate conception rates (CR) achieved with artificial insemination of Holstein cows using fresh or frozen insemination doses (ID). The synchronization protocols (Double-Ovsynch, Ovsynch, ReSynch) and pedometers were used
Jan Pytlík, Luděk Stádník, Jaromír Ducháček, Radim Codl   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Economic comparison of an ear tag automated activity monitor for estrus detection with timed-AI in Holstein heifers

, 2021
The objective of this study was to compare the economic performance of an ear tag automated activity monitor system (AAM) versus a timed-AI (TAI) protocol in Holstein heifers.
Colazo, M.G., Boyda, A., MacMillan, K., Gobikrushanth, M., Plastow, G.   +4 more
core   +1 more source

Timed artificial insemination plus heat I: effect of estrus expression scores on pregnancy of cows subjected to progesterone–estradiol-based protocols

Animal, 2019
Expression of estrus near timed artificial insemination (TAI) is associated with greater fertility, and estrus detection could improve TAI fertility or direct TAI management, although accurate estrus detection can be difficult and time-consuming using ...
E. Nogueira, M.R. Silva, J.C.B. Silva, U.P.G. Abreu, N.A. Anache, K.C. Silva, C.J.T. Cardoso, P. Sutovsky, W.B. Rodrigues   +8 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

EFFECT OF DOUBLE OR PRE-SYNCHRONIZATION OVSYNCH PROTOCOLS ON FOLLICULAR DYNAMICS, PROGESTERONE PROFILE AND FIRST SERVICE PREGNANCY RATE IN TIMED ARTIFICIAL INSEMINATION IN FRIESIAN COWS [PDF]

Journal of Animal and Poultry Production, 2015
Aim of this study was to determine the effect of double-Ovsynch (DO) and pre-synchronization (PS) protocols on ovarian follicular dynamics, progesterone (P4) concentration and pregnancy rate at first postpartum AI in Friesian cows.
M. Omar, M. El-Banna, M. El-Harairy
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Modifications of the G6G timed-AI protocol improved pregnancy per AI and reduced pregnancy loss in lactating dairy cows

Animal, 2017
In dairy cows, subjected to a G6G protocol, objectives were to determine effects of (1) extending the interval from prostaglandin F2α (PGF2α) to gonadotropin-releasing hormone (GnRH) during presynchronization; and (2) adding a second PGF2α treatment ...
F. Heidari, E. Dirandeh, Z. Ansari Pirsaraei, M.G. Colazo   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source