Results 51 to 60 of about 11,364 (306)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Effects of large follicle numbers at the onset of short-term timed artificial insemination protocol in lactating dairy cows

JDS Communications
This study aimed to compare the fertility of lactating Holstein cows with only 1 large follicle (LF, diameter ≥10 mm) with those with ≥2 LF and corpora lutea at the start of short-term ovulation synchronization and timed artificial insemination (AI ...
Kazuhiro Bandai, Ena Chiba, Toru Ogata, Yoshiyuki Tsuchiya, Tadaharu Ajito, Ryotaro Miura   +5 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

The Why’s, What’s, and How’s of Timed Artificial Insemination Programs

, 2015
This report summarizes the benefits of using timed artificial insemination (AI) programs in lactating dairy cows. Since its beginnings, use of Ovsynch has penetrated the dairy industry and is most prevalent in the Midwest and Northeast regions of the U.S.
L. Mendonca, Stevenson, J., J. Stevenson, Mendonca, L.   +3 more
core   +1 more source

A tool for the syntactic detection of zeno-timelocks in timed automata [PDF]

, 2005
Timed automata are a very successful notation for specifying and verifying real-time systems, but timelocks can freely arise. These are counter-intuitive situations in which a specifier's description of a component automaton can inadvertently prevent ...
Su, Li, Gomez, Rodolfo, Su, Linying, Bowman, Howard   +3 more
core   +1 more source

A single dose of FSH or hCG during a split-time AI program did not enhance follicular growth or pregnancy per artificial insemination in beef heifers

Journal of Applied Animal Research, 2023
The objective of this study was to evaluate the effect of a low dose of hCG or FSH on follicle growth and pregnancy per artificial insemination (AI) in crossbreed beef heifers subjected to a split-time AI program.
Daniella Heredia, Oscar Alejandro Ojeda-Rojas, Maria C. Londoño, Sergio D. Lasso, Rafael S. Bisinotto, Mario Binelli, Angela M. Gonella-Diaza   +6 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Effect of presynchronization with prostaglandin F-2 alpha before the 5-d timed AI protocol on ovarian responses and pregnancy in dairy heifers

, 2019
The objectives were the determine the effects of presynchronization with PGF(2)(alpha) 2 days before the 5-d timed artificial insemination (Al) protocol on ovarian responses and pregnancy per AI (P/AI) in dairy heifers.
Bisinotto, Rafael S., Santos, Jose Eduardo P., Karakaya, Ebru Bilen, Ribeiro, Eduardo S.   +3 more
core   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Improving fertility to timed artificial insemination by manipulation of circulating progesterone concentrations in lactating dairy cattle

, 2012
This manuscript reviews the effect of progesterone (P4) during timed AI protocols in lactating dairy cows. Circulating P4 is determined by a balance between P4 production, primarily by the corpus luteum (CL), and P4 metabolism, primarily by the ...
Alexandre H. Souza, Robb W. Bender, Milo C. Wiltbank, Paulo D. Carvalho, Anibal B. Nascimento   +4 more
core   +1 more source