Results 91 to 100 of about 168,490,903 (279)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Smart Light Fields

, 2009
Smart Light Fields is a live mapping of the movement of Smart Light Sydney festival-goers across Circular Quay. Also exhibited in the Creative Sydney Festival, Museum of Contemporary Art, Sydney.
Landreth, N, Coorey, BP, Hsu, S, Jakovich, J, Whiteley, C, McDermott, J   +5 more
core  

Light-Time Effect and Mass Transfer in the Triple Star SW Lyncis [PDF]

Journal of Astronomy and Space Sciences, 1999
In this paper all the photoelectric times of minimum for the triple star SW Lyn have been analyzed in terms of light-time e ect due to the third-body and secular period decreases induced by mass transfer process.
Chun-Hwey Kim
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The life and times of the Palo Alto Times

, 1992
Short history of the newspaper which started January 5, 1893.
Peninsula Times Tribune
core  

Protocol for a prospective, multicentre, cross-sectional cohort study to assess personal light exposure

BMC Public Health
Light profoundly impacts many aspects of human physiology and behaviour, including the synchronization of the circadian clock, the production of melatonin, and cognition. These effects of light, termed the non-visual effects of light, have been primarily
Carolina Guidolin, Sam Aerts, Gabriel Kwaku Agbeshie, Kwadwo Owusu Akuffo, Sema Nur Aydin, David Baeza-Moyano, John Bolte, Kai Broszio, Guadalupe Cantarero-García, Altug Didikoglu, Roberto Alonso González-Lezcano, Hongli Joosten-Ma, Sofía Melero-Tur, Maria Nilsson Tengelin, María Concepción Pérez Gutiérrez, Oliver Stefani, Ingemar Svensson, Ljiljana Udovičić, Johannes Zauner, Manuel Spitschan   +19 more
doaj   +1 more source

Period Change of W UMa Type Contact Binary AB And [PDF]

Journal of Astronomy and Space Sciences, 1997
The CCD photometric observations of W UMa-type eclipsing binary AB And were made from September 1994 to October 1996. New four primary minimum times were obtained form these observations.
Ho Jin, Wonyong Han, Chun-Hwey Kim, Jae-Woo Lee, Woo-Baik Lee   +4 more
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Comparing ISO 4049 and Fourier-transform infrared spectroscopy for assessing ambient light sensitivity in dental resin composites

Scientific Reports
This study evaluated the sensitivity of dental resin composites to ambient light using the ISO 4049 standard and Fourier-transform infrared (FTIR) spectroscopy.
Matej Par, Lucija Gotovac, Stella Horvat, Danijela Marovic, Zrinka Tarle, Tobias T. Tauböck, Thomas Attin, Lucija Ratkovski, Vlatko Panduric   +8 more
doaj   +1 more source