FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Does timing of decisions in a mixed duopoly matter? [PDF]
We determine the endogenous order of moves in a mixed price-setting duopoly. In contrast to the existing literature on mixed oligopolies we establish the payoff equivalence of the games with an exogenously given order of moves.
Balogh, Tamás L., Tasnádi, Attila
core
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Multi-Objective Optimization of Nitrogen Management for Oat Production in the Agro-Pastoral Ecotone of China Using NSGA-II to Balance Yield, Quality, Nitrogen Use Efficiency and Environmental Sustainability. [PDF]
Plants (Basel)Wang Y, Han X, Zhang Y, Wu X, Li L.
europepmc +1 more source
IPO investment strategies and pseudo market timing [PDF]
We analyse the performance of simple investment strategies in IPOs based on a large sample of IPOs in Germany between 1985 and 2002. In particular, we compare the performance of the following strategies: Invest equally weighted in each IPO, invest market
Trauten, Andreas, Schulz, Roland C.
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Endogenous timing in a mixed oligopoly consisting of a single public firm and foreign competitors [PDF]
We investigate endogenous timing in a mixed oligopoly consisting of a single public firm and foreign competitors and compare the results with those in Pal (1998) to see the effect of the nationality of private firms on the endogenous role of the public ...
Yuanzhu Lu
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Assessing the robustness of meta-analyses to variability in the frequency and timing of postoperative delirium assessment - a novel methodological approach. [PDF]
PLoS OneKhaled M +20 more
europepmc +1 more source