Results 191 to 200 of about 30,734 (250)

Plasma levels and systemic safety of 0.1% unpreserved Timolol maleate gel, 0.5% Timolol aqueous solution and 0.5% Timolol maleate gel

Journal Français d'Ophtalmologie, 2012
To compare systemic absorption of three formulations of timolol eye drops: 0.1% timolol maleate gel, 0.5% timolol aqueous solution, and 0.5% timolol maleate gel.This was a double cross-over phase I study. Cross-over 1: two weeks of 0.1% timolol gel once daily, followed by a 3-week wash-out period and then two weeks of 0.5% timolol aqueous solution ...
N, Bonnin, H, Nezzar, C, Dubray, D, Renault, C, Olmiere, F, Chiambaretta   +5 more
openaire   +2 more sources

Gelatinized core liposomes: A new Trojan horse for the development of a novel timolol maleate glaucoma medication.

International journal of pharmaceutics, 2019
Glaucoma treatment with ocular medications requires overcoming the corneal barrier to drug penetration. Liposomes have a great corneal penetration ability and affinity while suffering from poor stability and low entrapment of hydrophilic drugs ...
R. Hathout, Heba A. Gad, S. Abdel-Hafez, Nayera Nasser, Noha Khalil, Toka Ateyya, A. Amr, Nesreen Yasser, Sandra M Nasr, Abdelkader A. Metwally   +9 more
semanticscholar   +1 more source

Development of polymeric nanoparticle gel prepared with the combination of ionic pre-gelation and polyelectrolyte complexation as a novel drug delivery of timolol maleate

Drug Development and Industrial Pharmacy, 2020
Objective The purpose of this study was to overcome the undesired systemic absorption of skin topical administration of timolol maleate (TM) by developing the TM nanoparticle gel.
Wildan Khairi Muhtadi, Laras Novitasari, Retno Danarti, R. Martien   +3 more
semanticscholar   +1 more source

Differences in ocular surface irritation between timolol hemihydrate and timolol maleate

American Journal of Ophthalmology, 2000
We evaluated the anterior segment surface reaction findings between timolol hemihydrate and timolol maleate. The only known difference between these preparations is the maleate salt.After a baseline examination, we randomized 28 healthy subjects (26 completed) to timolol hemihydrate or timolol maleate given in both eyes twice daily, in a double masked ...
W C, Stewart, J A, Stewart, K T, Holmes, J N, Leech   +3 more
openaire   +2 more sources

Analysis of β-blocker timolol maleate drug residues in wastewater and biological fluids using differential pulse – anodic stripping voltammetry

International Journal of Environmental Analytical Chemistry, 2020
Drug residues in water represent one of the most serious environmental problems because of their high toxicity to the biological system. Thus, this study reports a low-cost strategy for fast and precise analysis of β- blocker timolol maleate (TM) using ...
G. I. Mohammed, Hossam Metwally Nassef, A. Bashammakh, Z. Saigl, M. El-Shahawi   +4 more
semanticscholar   +1 more source

Topical timolol maleate might adversely affect serum lipoproteins

International Ophthalmology, 1993
Conflicting observations have been reported about the effects of topically administered timolol maleate on serum lipoproteins. We therefore considered this issue in a series of eight glaucoma patients receiving timolol maleate. Cholesterol and triglycerides were measured in plasma and in low-density lipoproteins (LDL), and high-density lipoproteins ...
A B, Safran, F, Simona, A, Sansonetti, D, Pometta, R, James   +4 more
openaire   +2 more sources

Timolol maleate and HDL cholesterol after myocardial infarction

European Heart Journal, 1985
The influence of long-term timolol treatment on plasma lipids was analysed in cohorts of the Norwegian timolol multicentre study. The prognostic importance of high-density lipoprotein (HDL) cholesterol concentration after myocardial infarction was also examined. One year timolol treatment was related to a significant reduction in HDL cholesterol levels,
T, Gundersen, J, Kjekshus, O, Stokke, T, Pedersen   +3 more
openaire   +2 more sources

Corneal Anesthesia after Timolol Maleate Therapy

American Journal of Ophthalmology, 1979
Symptomatic superficial punctate keratitis associated with complete corneal anesthesia occurred in three patients after they had been taking timolol maleate for glaucoma. After discontinuation of the timolol maleate and substitution of conventional antiglaucomatous collyria, the keratitis gradually cleared with restoration of normal corneal sensitivity.
openaire   +2 more sources

Use of Topical Timolol Maleate as Re-Epithelialization Agent for Treatment of Recalcitrant Wounds of Varying Etiologies.

Journal of Drugs in Dermatology, 2020
Chronic wounds are a source of severe morbidity to patients.1 Wounds are also a notable burden on the healthcare system, with reported prevalence of 4.64% in the U.S. and an annual cost of over 25 billion dollars.2,3 Moreover, wounds are associated with >
Brian A. Cahn, R. Kaur, P. Hirt, C. Tchanque-Fossuo, S. Dahle, R. Kirsner, R. Isseroff, Hadar A. Lev-Tov   +7 more
semanticscholar   +1 more source

TIMOLOL MALEATE IN TREATMENT OF OPEN ANGLE GLAUCOMA

Acta Ophthalmologica, 1979
The effect of Timolol maleate on the intraocular pressure in open angle glaucoma has been examined in 37 patients, of these simple glaucoma in 26 (48 eyes), capsular glaucoma in 9 (14 eyes) and chronic secondary glaucoma in 2 patients (2 eyes). These cases constituded a group which was relatively difficult to manage.The average pressure reduction ...
H, Aasved, J H, Seland, J E, Slagsvold
openaire   +2 more sources