A novel reversed phase high performance liquid chromatography approach for stability-indicating simultaneous analysis of brimonidine tartrate and timolol maleate [PDF]
Frontiers in ChemistryIntroductionThe simultaneous quantification of Brimonidine Tartrate and Timolol Maleate in ophthalmic formulations is essential for ensuring product quality, efficacy, and stability.
Aktham Mestareehi, Aktham Mestareehi
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Poly(Sulfobetaine Methacrylate-co-Vinyl Pyrrolidone) Hydrogels as Potential Contact Lenses Delivery Systems for Timolol Maleate [PDF]
Gels, 2023 The study reveals the development of novel hydrogels based on sulfobetaine methacrylate (SB) and vinyl pyrrolidone (VP) copolymers as potential contact lenses delivery systems of timolol maleate (TM). The novel copolymer networks demonstrated composition
Denitsa Nikolova +3 more
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Topical Application of 0.5% Timolol Maleate Hydrogel for the Treatment of Superficial Infantile Hemangioma [PDF]
Frontiers in Oncology, 2017 The therapeutic options for infantile hemangiomas (IHs) have been greatly altered since the introduction of oral propranolol for successful treatments of IHs.
Hai Wei Wu +8 more
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A stability-indicating RP-HPLC method for the simultaneous quantification of brimonidine tartrate and timolol maleate in bulk drug substances and pharmaceutical dosage forms [PDF]
Scientific ReportsA robust, rapid, and reproducible reversed-phase high-performance liquid chromatography (RP-HPLC) method was developed and validated for the simultaneous quantification of Brimonidine Tartrate and Timolol Maleate (Combigan) in ophthalmic dosage forms ...
Aktham Mestareehi
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JAMA Ophthalmol, 2020 Importance Oral β-blockers used for the prevention of migraine headache are not effective for the treatment of acute pain. Small case series have suggested that topically applied β-blockers may be useful in the management of acute migraine pain ...
Kurian A +4 more
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Optimization of Thermoreversible In Situ Nasal Gel of Timolol Maleate [PDF]
Scientifica, 2016 Nasal route had shown better systemic bioavailability due to its large surface area, porous endothelial membrane, high total blood flow, and avoidance of first-pass metabolism.
Swati Jagdale +2 more
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Transdermal iontophoretic delivery of timolol maleate [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2012 Transdermal iontophoresis would be a promising method for the systemic delivery of water soluble and ionic drugs of relatively high molecular size, including peptides.
Mayur Patni +3 more
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Timolol Maleate Gel Forming Solution [PDF]
Definitions, 2020 A gel forming solution containing the maleate salt of timolol, a propanolamine derivative and a non-selective beta-adrenergic antagonist, with intraocular pressure-reducing activity.
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Safety and efficacy of switching from dorzolamide 1.0%/timolol maleate 0.5% eye drops to brinzolamide 1.0%/timolol maleate 0.5% eye drops [PDF]
Clinical Ophthalmology, 2015 Kenji Inoue,1 Minako Shiokawa,1 Kyoko Ishida,2 Goji Tomita2 1Inouye Eye Hospital, Tokyo, Japan; 2Department of Ophthalmology, Toho University Ohashi Medical Center, Tokyo, Japan Purpose: To evaluate the safety and efficacy of switching from dorzolamide
Inoue K, Shiokawa M, Ishida K, Tomita G
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Ocular reaction to timolol maleate [PDF]
Postgraduate Medical Journal, 1979 A patient prescribed timolol maleate for the control of hypertension developed dryness of the eyes. The symptoms improved on withdrawal of the drug. Vigilance for such adverse reactions must be observed in the use of any beta-adrenoreceptor blocking agent.
M A, Frais, T J, Bayley
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