Results 31 to 40 of about 11,035 (153)

Sustained Delivery of Timolol Maleate for Over 90 Days by Subconjunctival Injection. [PDF]

J Ocul Pharmacol Ther, 2016
Purpose: Medical treatment of glaucoma relies on intraocular pressure (IOP)-lowering medications, typically administered daily by the patient. While these medications are effective when applied correctly, patient adherence is a major obstacle in glaucoma
Lavik E, Kuehn MH, Shoffstall AJ, Atkins K, Dumitrescu AV, Kwon YH.   +5 more
europepmc   +2 more sources

Topical timolol maleate might adversely affect serum lipoproteins.

, 1993
Conflicting observations have been reported about the effects of topically administered timolol maleate on serum lipoproteins. We therefore considered this issue in a series of eight glaucoma patients receiving timolol maleate.
Pometta D, James R, Safran AB, Sansonetti A, Simona F   +4 more
core   +1 more source

Traction suture fixation technique using a capsular tension ring fragment for severe lens displacement during cataract surgery in dogs

Veterinary Ophthalmology, Volume 28, Issue 2, Page 197-206, March 2025.
Abstract Objectives To describe the traction suture fixation technique for severely displaced lenses (≥180°) using a capsular tension ring (CTR) fragment during cataract surgery in dogs, and to retrospectively investigate its clinical outcomes. Animals Studied Eight dogs (nine eyes). Procedures The medical records of dogs with severe lens displacement (
Shinya Fukumoto, Tomomi Minamoto
wiley   +1 more source

Carbon Paste Electrode with Au/Pd/MWCNT Nanocomposite for Nanomolar Determination of Timolol

International Journal of Electrochemical Science, 2017
Fabrication of Au/Pd/MWCNT nanocomposite was performed by using chemical method. The nanocomposite was characterized by scanning electron microscopy (SEM), energy-dispersive X-Ray spectroscopy (EDS) and electrochemical methods.
Khadijeh Nekoueian, Mandana Amiri, Mika Sillanpää   +2 more
doaj   +1 more source

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF DORZOLAMIDE AND TIMOLOL MALEATE IN PHARMACEUTICAL DOSAGE FORMS [PDF]

, 2012
A fast, sensitive and accurate reverse phase liquid chromatographic method was developed and validated for the simultaneous determination of Dorzolamide and Timolol maleate in ophthalmic preparations.
Mathrusri Annapurna, M., Narendra, A., Deepika, D.   +2 more
core   +1 more source

Development of an Efficient and Scalable Process for Preparing Timolol N‐Nitrosamine Impurities B, C, E, H, I, J, and Their ADMET Evaluation

Journal of Heterocyclic Chemistry, Volume 63, Issue 7, Page 1099-1113, July 2026.
N‐nitrosamine impurities (B, C, E, H, I, J) of timolol maleate are easily synthesized from diethyl malonate and 3,4‐dichloro‐1,2,5‐thiadiazole. Good yields and precise impurity profiling are made possible by the effective technique, which also ensures pharmaceutical safety and strengthens regulatory compliance.
Kottolla Sai Prasad, Chithaluri Sudhakar, Vijaya Krishna Ravi, Bijaya Kethan Sahoo   +3 more
wiley   +1 more source

Drop volume and cost of treatment with generic 0.5% timolol maleate preparations [PDF]

, 2004
PURPOSE: To compare drop volume and treatment cost of generic 0.5% timolol maleate preparations. METHODS: The drop volume of Timoptol® 0.5% (Merck Sharp & Dohme) and its generic preparations (Allergan-Lok, Cristália and Falcon) were determined.
Prata Junior, João Antonio [UNIFESP], Prata Junior, João Antonio, Prata, João Antonio   +2 more
core   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, Volume 13, Issue 36, 29 June 2026.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Innovative Drug Delivery Systems for the Treatment of Glaucoma

MedComm – Biomaterials and Applications, Volume 5, Issue 2, June 2026.
This review aims to provide a comprehensive overview of current topical drug delivery strategies for ocular hypotensive agents in glaucoma therapy. Additionally, it discusses the potential impact of emerging nanotechnological and biomaterial‐based systems in shaping the future of ophthalmic drug delivery, with an emphasis on enhancing efficacy, safety,
Jing Chu, Junzhi Li, Zhenlin Chen, Jinyu Zhang, Siqi Feng, Jiaying Huang, Yawen Chu, Xue Zhou, Wei Wang, Shangsi Chen   +9 more
wiley   +1 more source

A novel fixed-combination timolol-netarsudil-latanoprost ophthalmic solution for the treatment of glaucoma and ocular hypertension

Asian Journal of Pharmaceutical Sciences, 2022
Currently commercial fixed-concomitant three agents have multiple problems such as multiple dosing administration, poor efficacy and side effects. Once-daily fixed-combination timolol-netarsudil-latanoprost ophthalmic solution (FC-TNL) has the ability to
Tao Wang, Yunran Zhang, Meiling Chi, Chen Zhao, Linlin Cao, Chutong Tian, K. Kamei, Ying Zheng, Qikun Jiang   +8 more
doaj   +1 more source