Results 1 to 10 of about 13,983 (206)

Imbalances between matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in maternal serum during preterm labor [PDF]

PLoS ONE, 2012
Background: Matrix metalloproteinases (MMPs) are involved in remodeling of the extracellular matrix (ECM) during pregnancy and parturition. Aberrant ECM degradation by MMPs or an imbalance between MMPs and their tissue inhibitors (TIMPs) have been ...
Holtappels, Gabriële, KROES, IVO, Temmerman, Marleen, Tency, Inge, Vaneechoutte, Mario, Verhasselt, Bruno, Verhelst, Rita, Verstraelen, Hans   +7 more
core   +9 more sources

Temporal and Spatial Expression of Tissue Inhibitors of Metalloproteinases 1 and 2 (TIMP-1 and -2) in the Bovine Corpus Luteum [PDF]

Reproductive Biology and Endocrinology, 2011
The matrix metalloproteinases (MMPs) and their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs), may mediate the dramatic structural and functional changes in the corpus luteum (CL) over the course of its life span.
Moses, Marsha, Tsang, Paul CW, Zhang, Bo
core   +3 more sources

The urine biomarker panel [IGFBP7]x[TIMP-2] (NephroCheck® parameter) does not correlate with IGFBP7 and TIMP-2 gene expression in urinary sediment [PDF]

PLOS ONE, 2017
Acute kidney injury (AKI) is frequently observed in serious infections, following nephrotoxic medication, surgery and trauma. Here we tested whether the detection of two recently identified biomarkers for AKI, Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) and Insulin-Like Growth Factor Binding Protein 7 (IGFBP7), depends on the expression of these ...
Daniela Knafl, Markus Müller, Sahra Pajenda, Zeynep Genc, Manfred Hecking, Ludwig Wagner   +5 more
openaire   +4 more sources

Levels of MMP2, TIMP1 and TIMP2 in Follicular Fluids in Women Undergoing in Vitro Fertilization and Their Relationship to Oocyte Quality [PDF]

Journal of Biomedical & Clinical Research, 2019
Recently, the important role of matrix metalloproteinases (MMPs) has been identified in follicular development and subsequent ovulation. Although the role of MMP in ovarian tissue remodeling during folliculogenesis has been well studied, the relationship
Nina Ayvazova, Lyubomira Ilieva, Emiliana Konova, Milena Atanasova   +3 more
doaj   +3 more sources

Nephrotoxicity Biomarkers: Role and Significance in the Diagnosis of Drug-Induced Kidney Injury

Безопасность и риск фармакотерапии, 2021
Drug-induced kidney injury (DIKI) accounts for 8 to 60% of episodes of acute kidney injury (AKI) among hospital patients. Early DIKI detection and timely adjustment of therapy will help reduce the kidney injury incidence and mortality.
O. V. Muslimova, V. A. Evteev, I. A. Mazerkina, E. A. Sokova, A. B. Prokofiev, A. V. Shapchenko, T. V. Alexandrova   +6 more
doaj   +1 more source

Single value of NephroCheck™ performed at 4 hours after surgery does not predict acute kidney injury in off-pump coronary artery bypass surgery

Annals of Cardiac Anaesthesia, 2023
Background: Quantification of urinary tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor binding protein (IFGBP-7), which is commercially known as NephroCheck™(NC) test have been suggested as promising tools for the early ...
Muralidhar Kanchi, Karanam D Sudheshna, Srinath Damodaran, Vikneswaran Gunaseelan, Anup D Varghese, Kumar Belani   +5 more
doaj   +1 more source

Cell surface binding of TIMP‐2 and pro‐MMP‐2/TIMP‐2 complex [PDF]

FEBS Letters, 1995
Tissue inhibitor of metalloproteinases (TIMP‐2) is a low molecular weight proteinase inhibitor capable of inhibiting activated matrix metalloproteinases (MMPs). TIMP‐2 is found both free and in a 1:1 stoichiometric complex with the pro‐enzyme form of MMP‐2 (pro‐MMP‐2/TIMP‐2 complex).
Emmert-Buck, M. R., Emonard, H. P., Corcoran, M. L., Krutzscha, H. C., Foidart, Jean-Michel, Stetler-Stevenson, W. G.   +5 more
openaire   +3 more sources

TIMP-2 fusion protein with human serum albumin potentiates anti-angiogenesis-mediated inhibition of tumor growth by suppressing MMP-2 expression. [PDF]

PLoS ONE, 2012
TIMP-2 protein has been intensively studied as a promising anticancer candidate agent, but the in vivo mechanism underlying its anticancer effect has not been clearly elucidated by previous works.
Mi-Sook Lee, Jae-In Jung, Seung-Hae Kwon, Sang-Mok Lee, Kyoji Morita, Song Her   +5 more
doaj   +1 more source

Circulating levels of matrix proteases and their inhibitors in pregnant women with and without a history of recurrent pregnancy loss [PDF]

, 2010
Background: We have recently shown that serum relaxin-2 levels are attenuated in women with a history of recurrent pregnancy loss (RPL). We sought to determine whether a history of RPL is also associated with changes in serum matrix metalloproteases ...
Anumba, D.O.C., El Gelany, S., Elliott, S.L., Li, T.C.   +3 more
core   +3 more sources

Serum levels of matrix metalloproteinases-2 and-9 and their tissue inhibitors in inflammatory neuromuscular disorders [PDF]

, 2006
We monitored serum levels of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) before and during intravenously applied immunoglobulin (IVIG) therapy in 33 patients with chronic immune-mediated neuropathies and myopathies and 15 ...
B.G.H. Schoser, Carmeli E, Choi YC, D. Pongratz, Demestre M, Hartung HP, Kieseier BC, Kugler A, Lee MA, Mirowska D, S. Hurnaus, Schoser BGH, Shapiro S, Sharshar T, W. Mueller-Felber, Wiles CM   +15 more
core   +1 more source