Results 161 to 170 of about 191,310 (286)

A Network‐Based Approach to Understanding Key Signaling Pathways in Intervertebral Disc Biology

JOR SPINE, Volume 9, Issue 2, June 2026.
A literature‐based signaling network capturing the most relevant pathways in human nucleus pulposus cells was first constructed from curated biological evidence. The network was then translated into a system of ordinary differential equations to derive steady‐state solutions and define median baseline activity levels.
Sofia Tseranidou, Zerihun G. Workineh, Maria Segarra‐Queralt, Francis Kiptengwer Chemorion, Paola Bermudez‐Lekerika, Exarchos Kanelis, Katherine B. Crump, Benjamin Gantenbein, Leonidas G. Alexopoulos, Christine L. Le Maitre, Janet Piñero, Jérôme Noailly   +11 more
wiley   +1 more source

Exploring the Regulatory Function of NGAL in MMP-9 Complexes. [PDF]

Comput Struct Biotechnol J
Charzewski Ł, Krzyśko KA.
europepmc   +1 more source

Abcb4 Haploinsufficiency Sensitises Mice to a Diet‐Induced PSC‐Like Hepatobiliary Phenotype With Gallstone Formation

Liver International Communications, Volume 7, Issue 2, June 2026.
ABSTRACT ABCB4 translocates phospholipids (PL) into bile to buffer the toxicity of bile acids (BA) and free cholesterol (CHOL). While recessively inherited ABCB4 deficiency causes childhood Progressive Familial Intrahepatic Cholestasis type 3, haploinsufficiency has been linked to adult‐onset hepatobiliary diseases.
Eric L. Bell, Youhwa Jo, Jennifer K. Truong, Nathan O. Fuller, John P. Miller, Alastair S. Garfield, Robert O. Hughes   +6 more
wiley   +1 more source

Prospective cohort study of TIMP-1 and myocardial fibrosis in Chagas disease at a reference clinic in Pernambuco, Brazil: PTICH trial protocol. [PDF]

BMJ Open
Martins SM, Macedo CT, Meira CS, Paim Santos LH, Larocca TF, Cavalcanti da Silva FF, Leandro Lira CN, da Silva ÍPM, De Araujo LT, Soares MBP.   +9 more
europepmc   +1 more source

Phytotherapeutic Regulation of Matrix Metalloproteinases in Diabetic Foot Ulcer: Molecular Mechanisms and Wound Healing Perspectives

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
Chronic inflammation in diabetic foot ulcers elevates MMP activity and suppresses TIMP and growth factor signaling, impairing tissue repair. Phytochemicals modulate NF‐κB/MAPK pathways and enhance Nrf2–TIMP expression, restoring MMP/TIMP balance, promoting collagen deposition, angiogenesis, and re‐epithelialization, leading to effective wound healing ...
Vishnu Priyan Elaiyaraja, Eswara Rajagopal, Subhikssha Babu, Balaji Sadhasivam   +3 more
wiley   +1 more source

Exploratory transcriptomic analysis of mouse articular cartilage in response to tissue inhibitor of metalloproteinase 3 identifies inflammation-associated gene expression changes. [PDF]

Front Immunol
Mengozzi M, Towler B, Kwabiah J, Razmandeh F, Simoes F, Mullen L.   +5 more
europepmc   +1 more source

Distinct Roles of Myeloid‐ and Hepatocyte‐PLA2G6 Deletion in Mice With Metabolic Dysfunction‐Associated Steatotic Liver Disease

Liver International, Volume 46, Issue 6, June 2026.
ABSTRACT Background and Aims Polymorphisms of group VIA calcium‐independent phospholipase A2 (iPLA2β or PLA2G6) are associated with Type‐2 diabetes, blood lipids and inflammation. Global deficiency in iPLA2β‐null mice elicited protection against hepatic steatosis but not hepatic inflammation after high‐fat diet (HFD) feeding.
Gang Li, Simone Staffer, Sabine Tuma‐Kellner, Uta Merle, Walee Chamulitrat   +4 more
wiley   +1 more source

Functional divergence of LhcSR and PsbS in zeaxanthin‐mediated non‐photochemical quenching

New Phytologist, Volume 250, Issue 5, Page 3042-3052, June 2026.
Summary To protect photosystem II from excess light, non‐photochemical quenching (NPQ) dissipates excess energy as heat. NPQ relies on trigger proteins, LhcSR in algae and PsbS in vascular plants, and the light‐regulated xanthophyll cycle, which interconverts violaxanthin and zeaxanthin through the opposite activities of violaxanthin de‐epoxidase and ...
Claudia Beraldo, Cleo Bagchus, Dana Verhoeven, Alessandra Bellan, Caterina Gerotto, Emilie Wientjes, Herbert van Amerongen, Tomas Morosinotto, Alessandro Alboresi   +8 more
wiley   +1 more source

An RNA structural switch controlling bacterial toxin translation. [PDF]

Nucleic Acids Res
Eleftheraki A, Escalera-Maurer A, Hien EDM, Virciglio A, Conangle M, Tourasse NJ, Le Rhun A, Holmqvist E.   +7 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, Volume 16, Issue 5, Page 821-836, May 2026.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source