Results 11 to 20 of about 141,946 (275)

MMP–TIMP interaction depends on residue 2 in TIMP‐4 [PDF]

FEBS Letters, 2001
Extracellular matrix remodeling and degradation are of great importance in both physiological and pathological situations. Matrix metalloproteinases (MMPs) and their natural occurring inhibitors – tissue inhibitors of metalloproteinases (TIMPs) – are involved in matrix turnover. Among the TIMPs there is only little specificity for inhibiting individual
Stratmann, B, Farr, M, Tschesche, Harald
openaire   +4 more sources

Comparative studies of TIMP-1 immunohistochemistry, TIMP-1 FISH analysis and plasma TIMP-1 in glioblastoma patients [PDF]

Journal of Neuro-Oncology, 2016
Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been associated with poor prognosis and resistance towards chemotherapy in several cancer forms. In a previous study we found an association between a low TIMP-1 tumor immunoreactivity and increased survival for glioblastoma patients, when compared to moderate and high TIMP-1 tumor immunoreactivity.
Aaberg-Jessen, Charlotte, Halle, Bo, Jensen, Stine Skov, Muller, Sven, Rømer, Maria Unni Koefoed, Pedersen, Christian B., Brünner, Nils, Kristensen, Bjarne Winther   +7 more
openaire   +8 more sources

The in vitro activity of ADAM‐10 is inhibited by TIMP‐1 and TIMP‐3 [PDF]

FEBS Letters, 2000
A recombinant soluble form of the catalytic domain of human ADAM‐10 was expressed as an Fc fusion protein from myeloma cells. The ADAM‐10 was catalytically active, cleaving myelin basic protein and peptides based on the previously described ‘metallosheddase’ cleavage sites of tumour necrosis factor α, CD40 ligand and amyloid precursor protein.
Amour, Augustin, Knight, C.Graham, Webster, Ailsa, Slocombe, Patrick M., Stephens, Paul E., Knäuper, Vera, Docherty, Andrew J.P., Murphy, Gillian   +7 more
openaire   +4 more sources

Expression of Tissue Inhibitors of Metalloproteinases (TIMP-1, TIMP-2, TIMP-3, TIMP-4) in Blood Serum of Patients with Keratoconus

Journal of Clinical Medicine
Background: The etiology of keratoconus is unclear. Current evidence suggests that inflammatory and systemic mechanisms might play a role in its pathophysiology. The proper interaction of proteolytic enzymes—matrix metalloproteinases—and their specific tissue inhibitors (TIMPs) within the cornea is essential in maintaining its structure, transparency ...
Marta Nowak-Wąs, Paweł Wąs, Zenon Czuba, Romuald Wojnicz, Dorota Wyględowska-Promieńska   +4 more
openaire   +3 more sources

Autophagy Orchestrates Anti-Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP-2 Axis in Colorectal Cancer. [PDF]

Adv Sci (Weinh)
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Cheng B, Wei C, Niu Z, Chen J, Long G, Weng Y, Liu Q, Jiang Y, Wang P, Zhang R, Yu Q, Wu X, Wang W.   +12 more
europepmc   +2 more sources

Differential expression and localization of TIMP-1 and TIMP-4 in human gliomas [PDF]

British Journal of Cancer, 2001
Studies have suggested that an imbalance of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) may contribute to the malignant phenotype of gliomas. In this study, we have undertaken a detailed analysis of expression of the TIMP family in normal human brain and malignant gliomas at both the mRNA and protein level ...
Groft, L.L., Muzik, H., Rewcastle, N.B., Johnston, R.N., Knauper, V., Lafleur, M.A., Forsyth, P.A., Edwards, D.R.   +7 more
openaire   +4 more sources

E. coli Expression of TIMP-4 and Comparative Kinetic Studies with TIMP-1 and TIMP-2:  Insights into the Interactions of TIMPs and Matrix Metalloproteinase 2 (Gelatinase A)

Biochemistry, 2002
The inhibitory properties of TIMP-4 for matrix metalloproteinases (MMPs) were compared to those of TIMP-1 and TIMP-2. Full-length human TIMP-4 was expressed in E. coli, folded from inclusion bodies, and the active component was purified by MMP-1 affinity chromatography. Progress curve analysis of MMP inhibition by TIMP-4 indicated that association rate
Troeberg, Linda, Tanaka, Mitsuo, Wait, Robin, Shi, Yeunian E, Brew, Keith, Nagase, Hideaki   +5 more
openaire   +5 more sources

Modulation of plasma matrix metalloproteinase 9 and its inhibitors by vitamin D. [PDF]

, 2012
PhDMatrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are upregulated in a variety of diseases. Hypothesis: As TIMP-1 levels are elevated in liver fibrosis, might a similar process occur in essential hypertension driven left ...
Timms, Peter McLean
core   +4 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Dependence of TIMP-1 plasma levels on preanalytical specimen handling [PDF]

, 2008
Background: Tissue inhibitor of metalloproteinases-1 (TIMP-1) in blood might be a helpful biomarker in various diseases. However, various authors report that TIMP-1 is dependent on preanalytical procedures.
Doss, Robert, Dorothea Nagel, Barry Dowell, Stieber, Petra, Marie Dresse, Dowell, Barry, Dresse, Marie, Robert Doss, Davis, Gerard, Ganser, Eva-Maria, Gerard Davis, Eva-Maria Ganser, Nagel, Dorothea, Petra Stieber   +13 more
core   +1 more source