Results 31 to 40 of about 141,946 (275)

Remodeling Factors, Transcription Factors and Angiogenetic Factors in Cholesteatoma in Ontogenetic Aspect [PDF]

Iranian Journal of Otorhinolaryngology, 2022
Introduction:The main goal of our study was to describe the transcription factor (NF-κβ), angiogenetic factor (VEGF), and remodeling markers (MMP-9 and TIMP-4) of the cholesteatoma tissue compared to control skin tissue. There are still uncertainties how
Kristaps Dambergs, Gunta Sumeraga, Māra Pilmane   +2 more
doaj   +1 more source

Serum Tissue Inhibitor of Metalloproteinase 1 and 2 (TIMP-1 and TIMP-2) Levels in Colorectal Cancer Patients: Associations with Clinicopathological Variables and Patient Survival

The International Journal of Biological Markers, 2009
Tissue inhibitors of metalloproteinases (TIMPs) appear to affect many aspects of cancer biology, playing a crucial role in cell signaling by regulating cell growth, apoptosis, invasion, metastasis, angiogenesis, and genomic instability.
Constantinos Giaginis, Nikolaos Nikiteas, Alexandra Margeli, Nikolaos Tzanakis, Georgios Rallis, Gregorios Kouraklis, Stamatios Theocharis MD, PhD   +6 more
doaj   +1 more source

Imbalance of tissue inhibitors of metalloproteinases (TIMP) – 1 and – 4 serum levels, in patients with inflammatory bowel disease

BMC Gastroenterology, 2008
Background Tissue inhibitors of metalloproteinases (TIMPs) play a key role in tissue degradation and remodeling. Since chronic inflammation is associated with tissue remodeling in inflammatory bowel disease (IBD), we evaluated serum TIMP-1 and TIMP-4 ...
Theodoridou Aikaterini T, Mylonis Petros I, Manolakis Anastasios C, Lotis Vasilios D, Davidi Ioanna P, Kapsoritaki Anastasia I, Kapsoritakis Andreas N, Germenis Anastasios E, Potamianos Spyros P   +8 more
doaj   +1 more source

TIMP-1 is upregulated, but not essential in hepatic fibrogenesis and carcinogenesis in mice

Scientific Reports, 2017
Tissue inhibitor of metalloproteinases-1 (TIMP-1) is upregulated during hepatic fibrogenesis and considered to promote fibrosis in the injured liver by inhibition of matrix metalloproteases (MMP) and degradation of extracellular matrix.
Nina D. Thiele, Jan W. Wirth, David Steins, Anja C. Koop, Harald Ittrich, Ansgar W. Lohse, Johannes Kluwe   +6 more
doaj   +1 more source

Co-expression of TIMP-1 and its cell surface binding partner CD63 in glioblastomas

BMC Cancer, 2018
Background We have previously identified tissue inhibitor of metalloproteinases-1 (TIMP-1) as a prognostic marker in glioblastomas. TIMP-1 has been associated with chemotherapy resistance, and CD63, a known TIMP-1-binding protein, has been suggested to ...
Charlotte Aaberg-Jessen, Mia D. Sørensen, Ana L. S. A. Matos, José M. Moreira, Nils Brünner, Arnon Knudsen, Bjarne W. Kristensen   +6 more
doaj   +1 more source

Polymorphism of angiogenesis regulation factor genes (VEGF/VEGFR), and extracellular matrix remodeling genes (MMP/TIMP), and the levels of their products in extracellular tissues of patients with primary and secondary lymphedema

Вавиловский журнал генетики и селекции
Cells of various organs and systems perform their functions and intercellular interactions not in an inert environment, but in the microenvironment of tissue fluids. Violations of the normal drainage of tissue fluids accompany lymphedema.
V. I. Konenkov, V. V. Nimaev, A. V. Shevchenko, V. F. Prokofiev   +3 more
doaj   +1 more source

Tissue inhibitor of metalloproteinase-3 (TIMP-3) regulates hematopoiesis and bone formation in vivo. [PDF]

PLoS ONE, 2010
BACKGROUND: Tissue inhibitor of metalloproteinases-3 (TIMP-3) inhibits matrix metalloproteinases and membrane-bound sheddases. TIMP-3 is associated with the extracellular matrix and is expressed in highly remodeling tissues.
Yi Shen, Ingrid G Winkler, Valerie Barbier, Natalie A Sims, Jean Hendy, Jean-Pierre Lévesque   +5 more
doaj   +1 more source

Human keratinocyte cell lines differ in the expression of the collagenolytic matrix metalloproteinases-1,-8, and-13 and of TIMP-1 [PDF]

, 2000
Bachmeier BE, Nerlich AG, Boukamp P, et al. Human keratinocyte cell lines differ in the expression of the collagenolytic matrix metalloproteinases-1,-8, and-13 and of TIMP-1. BIOLOGICAL CHEMISTRY.
Boukamp, P, Tschesche, Harald, Bachmeier, BE, Bachmeier, B. E., Nerlich, A. G., Fink, E., Fritz, H, Fink, E, Fritz, H., Tschesche, H., Lichtinghagen, R., Nerlich, AG, Lichtinghagen, R, Boukamp, P.   +13 more
core   +1 more source

TIMP-2 fusion protein with human serum albumin potentiates anti-angiogenesis-mediated inhibition of tumor growth by suppressing MMP-2 expression. [PDF]

PLoS ONE, 2012
TIMP-2 protein has been intensively studied as a promising anticancer candidate agent, but the in vivo mechanism underlying its anticancer effect has not been clearly elucidated by previous works.
Mi-Sook Lee, Jae-In Jung, Seung-Hae Kwon, Sang-Mok Lee, Kyoji Morita, Song Her   +5 more
doaj   +1 more source

TIMP-1 Induces α-Smooth Muscle Actin in Fibroblasts to Promote Urethral Scar Formation

Cellular Physiology and Biochemistry, 2015
Background/Aims: Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been reported to upregulate in urethral scar. However, the underlying molecular mechanisms remain undefined.
Yinglong Sa, Chao Li, Hongbin Li, Hailin Guo   +3 more
doaj   +1 more source