Results 51 to 60 of about 141,946 (275)

Causal correlations between inflammatory proteins and heart failure: A two‐sample Mendelian randomization analysis

ESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.
Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu, Gui‐Qin Liu, Ya‐Ping Peng, Li‐Ling Zhang, Xian‐Jin Wang, Liang‐Chuan Chen, Yuan‐Xi Zheng, Xue‐Jun Xiang, Rui Qiao, Xian‐He Lin   +9 more
wiley   +1 more source

TIMP-1 Modulation Correlates with KRAS Dependency and EMT Induction in NSCLC

Cells
Kirsten rat sarcoma viral oncogene homolog (KRAS) is one of the most frequently mutated genes in human cancer, including non-small cell lung carcinoma (NSCLC). Sustained expression of KRAS is required for survival in KRAS-dependent tumors.
Ilamathi M-Thirusenthilarasan, Pankaj Ahluwalia, Nithyananda Thorenoor, Sampa Ghoshal-Gupta, Byung Rho Lee, Bilal Siddiqui, Ravindra Kolhe, Amyn M. Rojiani, Mumtaz V. Rojiani   +8 more
doaj   +1 more source

Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation. [PDF]

PLoS ONE, 2012
Prediction of therapeutic response and cancer patient survival can be improved by the identification of molecular markers including tumor Akt status. A direct correlation between NOS2 expression and elevated Akt phosphorylation status has been observed ...
Lisa A Ridnour, Kimberly M Barasch, Alisha N Windhausen, Tiffany H Dorsey, Michael M Lizardo, Harris G Yfantis, Dong H Lee, Christopher H Switzer, Robert Y S Cheng, Julie L Heinecke, Ernst Brueggemann, Harry B Hines, Chand Khanna, Sharon A Glynn, Stefan Ambs, David A Wink   +15 more
doaj   +1 more source

TIMP-3 overexpression in hVSMCs induces apoptosis.

, 2018
A and B. Nuclear fragmentation measured by DAPI staining (examples in A for RAd60 and RAdT3, scale bar = 20 μm) expressed as percentage of total nuclei count for VSMCs infected with control adenoviral particles (RAd60), TIMP-3 expressing adenovirus ...
Martin R. Bennett (254940), Andrew H. Baker (238639), Heather Ireland-Zecchini (5059316), William R. English (184202), Trevor D. Littlewood (5059319), Gillian Murphy (152249)   +5 more
core   +1 more source

Expression level and glycan dynamics determine the net effects of TIMP-1 on cancer progression [PDF]

BMB Reports, 2012
Tissue inhibitor of metalloproteinases (TIMPs; TIMP-1, -2, -3 and-4) are endogenous inhibitor for matrix metalloproteinases(MMPs) that are responsible for remodeling the extracellularmatrix (ECM) and involved in migration, invasion and metastasisof tumor
Yong-Sam Kim, Sun-Hee Kim, Jeong-Gu Kang & Jeong-Heon Ko*
doaj  

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Is the expression of matrix metalloproteinases (MMP-2, -9) and tissue inhibitors of metalloproteinases (TIMP-1, -2, and -3) associated with angiogenesis and clinicopathological features for breast cancer?

Journal of Health Sciences, 2017
Introduction: Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are involved in the progression of several tumors, including breast cancer. Our aim was to investigate the association of immunohistochemical expression of
Suada Kuskunović-Vlahovljak, Nina Čamdžić, Svjetlana Radović, Mirsad Dorić, Mirsad Babić, Edina Lazović Salčin, Lejla Džananović   +6 more
doaj   +1 more source

Tissue inhibitor of metalloproteinase-3 knockout mice exhibit enhanced energy expenditure through thermogenesis. [PDF]

PLoS ONE, 2014
Tissue inhibitors of metalloproteinases (TIMPs) regulate matrix metalloproteinase activity and maintain extracellular matrix homeostasis. Although TIMP-3 has multiple functions (e.g., apoptosis, inhibition of VEGF binding to VEGF receptor, and inhibition
Yohsuke Hanaoka, Osamu Yasuda, Hirofumi Soejima, Keishi Miyata, Eiichiro Yamamoto, Yasuhiro Izumiya, Nobuyo Maeda, Mitsuru Ohishi, Hiromi Rakugi, Yuichi Oike, Shokei Kim-Mitsuyama, Hisao Ogawa   +11 more
doaj   +1 more source

Identification of a novel 82 kDa proMMP-9 species associated with the surface of leukaemic cells [PDF]

, 2007
MMP-9 (matrix metalloproteinase 9) plays a critical role in tumour progression. Although the biochemical properties of the secreted form of proMMP-9 are well characterized, little is known about the function and activity of cell surface-associated proMMP-
Mentele, Reinhard, Egea, Virginia, Jochum, Marianne, Ries, Christian, Zahler, Stefan, Nagase, Hideaki, Pitsch, Thomas   +6 more
core   +1 more source

Targeting Renal IGFBP7 With Tetrahedral Framework Nucleic Acid‐Delivered siRNA Alleviates Acute Kidney Injury

iNew Medicine, EarlyView.
A tFNA‐based siRNA delivery system targeting IGFBP7 effectively silences IGFBP7 expression and attenuates renal dysfunction, tubular injury, and cell death in both septic (CLP) and ischemic (I/R) murine models of acute kidney injury. ABSTRACT Objective Acute kidney injury (AKI) is a common and serious clinical condition, yet effective targeted ...
Shao‐qi Wu, Ying‐ying Gao, Meng‐yi Jia, Yu‐Hao Liu, Qian Zhou, Dong Liu, Yu Ren, Yu‐jie Liu, Feng‐he Li, Ya‐ru Yang, Jie Wang, Jia‐gen Wen   +11 more
wiley   +1 more source