Results 71 to 80 of about 191,310 (286)

Differential expression and localization of TIMP-1 and TIMP-4 in human gliomas [PDF]

British Journal of Cancer, 2001
Studies have suggested that an imbalance of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) may contribute to the malignant phenotype of gliomas. In this study, we have undertaken a detailed analysis of expression of the TIMP family in normal human brain and malignant gliomas at both the mRNA and protein level ...
Groft, L.L., Muzik, H., Rewcastle, N.B., Johnston, R.N., Knauper, V., Lafleur, M.A., Forsyth, P.A., Edwards, D.R.   +7 more
openaire   +3 more sources

Anifrolumab Treatment Leads to Rapid Reduction in Urinary Biomarkers of Intrarenal Inflammation in Lupus Nephritis: Results From the Phase 2 Randomized Trial

Arthritis &Rheumatology, EarlyView.
Objective Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE) and is partially driven by type I interferon signaling. Anifrolumab, an approved treatment for patients with SLE, has been investigated in a phase 2 trial in patients with LN receiving standard therapy (TULIP‐LN, ClinicalTrials.gov identifier ...
Andrea Fava, Michelle Petri, Patrick G. Gavin, Eszter Csomor, Philip Z. Brohawn, Daniel Muthas, Adam Platt, Catharina Lindholm, Nicola Ferrari   +8 more
wiley   +1 more source

Identification of a novel 82 kDa proMMP-9 species associated with the surface of leukaemic cells [PDF]

, 2007
MMP-9 (matrix metalloproteinase 9) plays a critical role in tumour progression. Although the biochemical properties of the secreted form of proMMP-9 are well characterized, little is known about the function and activity of cell surface-associated proMMP-
Egea, Virginia, Jochum, Marianne, Mentele, Reinhard, Nagase, Hideaki, Pitsch, Thomas, Ries, Christian, Zahler, Stefan   +6 more
core   +1 more source

Vitamins as potent cancer treatments through regulating the activity and expression of MMP‐2 and MMP‐9

Bulletin of the Korean Chemical Society, EarlyView.
Vitamins could regulate both MMP‐2 and MMP‐9 expression and activity through transcriptional and MAPK signaling pathway modulation. This study highlights the potential of vitamins as low‐toxicity therapeutic or adjunct agents for targeting MMP‐mediated cancer progression. Abstract Matrix metalloproteinases (MMP‐2 and MMP‐9) are key regulators of cancer
Yen Thi Nguyen, Eungchan Kim, Ha Vy Thi Vo, Song Ja Kim, Namdoo Kim, Hyuck Jin Lee   +5 more
wiley   +1 more source

Imunomarcação de metaloproteinases 9 (MMP-9) e 2 (MMP-2) e seus inibidores (TIMP-1) e (TIMP-2) no tecido mamário canino normal e neoplásico

Ciência Animal Brasileira, 2020
Este estudo teve como objetivo realizar a imunomarcação de MMP-9 e MMP-2 e seus inibidores, TIMP-1 e TIMP-2, no tecido mamário canino normal e neoplásico, a fim de avaliar o comportamento dessas proteínas no remodelamento da matriz extracelular (MEC) em ...
Hugo Henrique Ferreira, Denise Caroline Toledo, Adriana Marques Faria, Diego Pereira Araújo, Andrigo Barboza di Nardi, Regiani Nascimento Gagno Porto, Veridiana Maria Brianezi Dignani de Moura   +6 more
doaj  

Evaluation of Sample Handling in Relation to Levels of Tissue Inhibitor of Metalloproteinases-1 Measured in Blood by Immunoassay

The International Journal of Biological Markers, 2003
Background The possible effect of preanalytical conditions such as blood sample preparation and handling on TIMP-1 levels in blood needs thorough investigation.
M.N. Holten-Andersen, A.-S. Schrohl, N. Brünner, H.J. Nielsen, C.K. Høgdall, E.V.S. Høgdall   +5 more
doaj   +1 more source

Successive Release of Tissue Inhibitors of Metalloproteinase-1 Through Graphene Oxide-Based Delivery System Can Promote Skin Regeneration

Nanoscale Research Letters, 2017
The purpose of this study was to testify the hypothesis that graphene oxide (GO) could act as an appropriate vehicle for the release of tissue inhibitors of metalloproteinase-1 (TIMP-1) protein in the context of skin repair.
Cheng Zhong, Dike Shi, Yixiong Zheng, Peter J. Nelson, Qi Bao   +4 more
doaj   +1 more source

Tissue inhibitor of metalloproteinase-3 knockout mice exhibit enhanced energy expenditure through thermogenesis. [PDF]

PLoS ONE, 2014
Tissue inhibitors of metalloproteinases (TIMPs) regulate matrix metalloproteinase activity and maintain extracellular matrix homeostasis. Although TIMP-3 has multiple functions (e.g., apoptosis, inhibition of VEGF binding to VEGF receptor, and inhibition
Yohsuke Hanaoka, Osamu Yasuda, Hirofumi Soejima, Keishi Miyata, Eiichiro Yamamoto, Yasuhiro Izumiya, Nobuyo Maeda, Mitsuru Ohishi, Hiromi Rakugi, Yuichi Oike, Shokei Kim-Mitsuyama, Hisao Ogawa   +11 more
doaj   +1 more source

Fermented mistletoe extract as a multimodal antitumoral agent in gliomas [PDF]

, 2012
In Europe, commercially available extracts from the white-berry mistletoe (Viscum album L.) are widely used as a complementary cancer therapy. Mistletoe lectins have been identified as main active components and exhibit cytotoxic effects as well as ...
Harter, Patrick Nikolaus, Mittelbronn, Michel Guy André, Naumann, Ulrike, Podlech, Oliver, Pöschel, Simone   +4 more
core   +2 more sources

Assessment of the immunomodulatory properties of the probiotic strain Lactobacillus paracasei K5 in vitro and in vivo [PDF]

, 2020
Lactobacillus paracasei K5 is a lactic acid bacteria (LAB) strain that has been isolated from dairy products. Previous studies have established its probiotic potential in a series of in vitro tests, including molecular characterization, safety profiling,
Alexopoulos, Athanasios, Bezirtzoglou, Eugenia, Botaitis, Sotiris, Chondrou, Pelagia, Galanis, Alex, Karapetsas, Athanasios, Kiousi, Despoina Eugenia, Plessas, Stavros, Vasileiadis, Stavros, Ypsilantis, Petros   +9 more
core   +2 more sources