Results 61 to 70 of about 141,946 (275)

Imunomarcação de metaloproteinases 9 (MMP-9) e 2 (MMP-2) e seus inibidores (TIMP-1) e (TIMP-2) no tecido mamário canino normal e neoplásico

Ciência Animal Brasileira, 2020
Este estudo teve como objetivo realizar a imunomarcação de MMP-9 e MMP-2 e seus inibidores, TIMP-1 e TIMP-2, no tecido mamário canino normal e neoplásico, a fim de avaliar o comportamento dessas proteínas no remodelamento da matriz extracelular (MEC) em ...
Hugo Henrique Ferreira, Denise Caroline Toledo, Adriana Marques Faria, Diego Pereira Araújo, Andrigo Barboza di Nardi, Regiani Nascimento Gagno Porto, Veridiana Maria Brianezi Dignani de Moura   +6 more
doaj  

TIMP-1 Contact Sites and Perturbations of Stromelysin 1 Mapped by NMR and a Paramagnetic Surface Probe^†

, 2016
Surfaces of the 173 residue catalytic domain of human matrix metalloproteinase 3 (MMP-3(ΔC)) affected by binding of the N-terminal, 126 residue inhibitory domain of human TIMP-1 (N-TIMP-1) have been investigated using an amide-directed, NMR-based ...
Ko Suzuki (2950017), Naoki Yoshida (504407), Mark Berjanskii (2950020), Steven R. Van Doren (1316193), Christopher L. Hemme (522105), Hideaki Nagase (1902), Bin Wu (138543), S. Arumugam (2948010)   +7 more
core   +1 more source

The Effects of Angiotensin Receptor Neprilysin Inhibitor on Endoplasmic Reticulum Stress in Doxorubicin‐Mediated Cardiomyopathy‐Associated Heart Failure Model in Rats

Journal of Applied Toxicology, EarlyView.
ABSTRACT One of the most serious complications associated with the use of the chemotherapeutic agent doxorubicin (DOX) is cardiomyopathy. Although cardioprotective drugs such as angiotensin receptor‐neprilysin inhibitors (ARNI) are used to prevent cardiomyopathy in DOX patients, no studies have reported the relationship between ARNI and endoplasmic ...
Mert Unvan, Meryem İlkay Karagül, Hatice Oruç Demirbağ, Ebru Balli   +3 more
wiley   +1 more source

Study of Matrix Metalloproteinases and Their Inhibitors in Blood Serum of Healthy Men of Different Ages Exposed to Risk Factors

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье
Aging is an irreversible process that proceeds individually in each case. It is known that the matrix metalloproteinase (MMP) system is involved in processes associated with aging.
E. V. Markelova, V. N. Yushchuk, N. S. Chepurnova, M. A. Visyagina, S. V. Knysh, E. A. Chagina   +5 more
doaj   +1 more source

Evaluation of Sample Handling in Relation to Levels of Tissue Inhibitor of Metalloproteinases-1 Measured in Blood by Immunoassay

The International Journal of Biological Markers, 2003
Background The possible effect of preanalytical conditions such as blood sample preparation and handling on TIMP-1 levels in blood needs thorough investigation.
M.N. Holten-Andersen, A.-S. Schrohl, N. Brünner, H.J. Nielsen, C.K. Høgdall, E.V.S. Høgdall   +5 more
doaj   +1 more source

2-Hydroxyethyl Methacrylate Increases MMP-1 and MMP-3 Production in Human Gingival Fibroblasts. [PDF]

J Biochem Mol Toxicol
HEMA induces the production of MMP‐1 and MMP‐3 in human gingival fibroblasts by activating the p38 MAPK, JNK, and Akt signaling pathways. ABSTRACT 2‐Hydroxyethyl methacrylate (HEMA), a monomer commonly used in dental resin materials, has been reported to leach from polymerized resins.
Okamoto R, Hosokawa Y, Hosokawa I, Fukui A, Miyake N, Ozaki K, Hosaka K.   +6 more
europepmc   +2 more sources

TIMP-3 overexpression induces apoptosis via a type-I death receptor pathway in hVSMCs.

, 2018
A. Western blot of lysates of VSMCs infected with either control (RAd60) or TIMP-3 (RAdT3)-expressing adenovirus harvested at the indicated times. Western blots were probed with anti-caspase-8, which can detect the pro, processed and 18 kDa active forms (
Martin R. Bennett (254940), Andrew H. Baker (238639), Heather Ireland-Zecchini (5059316), William R. English (184202), Trevor D. Littlewood (5059319), Gillian Murphy (152249)   +5 more
core   +1 more source

TRIM Expression and Its Association With Disease Activity in Systemic Lupus Erythematosus

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse manifestations, including rash, arthritis, and nephritis. Although autoantibodies are a key feature of SLE, their levels often poorly reflect disease severity, suggesting the involvement of additional contributing factors.
Ling‐Ying Lu, Ling‐Jung Yen, Hui‐Ling Hsia, Zi‐Xeng Weng, Chi‐Hsiang Chung, Paul Wei‐Che Hsu, Chih‐Wei Chiu, Wu‐Chien Chien, Tsung‐Hsien Chang   +8 more
wiley   +1 more source

Successive Release of Tissue Inhibitors of Metalloproteinase-1 Through Graphene Oxide-Based Delivery System Can Promote Skin Regeneration

Nanoscale Research Letters, 2017
The purpose of this study was to testify the hypothesis that graphene oxide (GO) could act as an appropriate vehicle for the release of tissue inhibitors of metalloproteinase-1 (TIMP-1) protein in the context of skin repair.
Cheng Zhong, Dike Shi, Yixiong Zheng, Peter J. Nelson, Qi Bao   +4 more
doaj   +1 more source

A Randomized Controlled Trial of Dual Upper‐Extremity Training [DUET]: Combining Neurologic Music Therapy® with Noninvasive Brain Stimulation for Upper‐Limb Performance in Corticobasal Syndrome

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Corticobasal syndrome (CBS) is a progressive neurodegenerative condition characterized by asymmetric limb rigidity, apraxia, dystonia, and myoclonus, with no approved symptomatic or disease‐modifying drug treatments. Neurologic music therapy (NMT)® employs evidence‐based techniques targeting sensorimotor rehabilitation, and high ...
Kyurim Kang, Isabella Sterner, Shriya Bakhshi, Chris Bedell, Alexander Pantelyat   +4 more
wiley   +1 more source