Results 61 to 70 of about 191,310 (286)

Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis. [PDF]

, 2016
The invasion-promoting MT1-MMP is a cell surface-associated collagenase with a plethora of critical cellular functions. There is a consensus that MT1-MMP is a key protease in aberrant pericellular proteolysis in migrating cancer cells and, accordingly, a
Cieplak, Piotr, Ge, Xin, Nam, Dong Hyun, Remacle, Albert G, Shiryaev, Sergey A, Strongin, Alex Y   +5 more
core   +1 more source

Diagnostic Odyssey of Atypical Long‐Chain 3‐Hydroxyacyl‐CoA Dehydrogenase Deficiency (LCHADD) Explained by Three Allelic Products From Two Pathogenic Variants

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency (LCHADD) is an autosomal recessive mitochondrial defect of long‐chain fatty acid β‐oxidation, caused by biallelic pathogenic variants in HADHA or HADHB. We report a 22‐year‐old male with an atypically mild presentation of LCHADD who was referred to the Undiagnosed Diseases Network (UDN ...
Yutaka Furuta, Lynette C. Rives, T. Andrew Burrow, Thomas A. Cassini, Rory J. Tinker, Amy K. Robertson, Kimberly M. Ezell, Rizwan Hamid, Joy D. Cogan, John A. Phillips III   +9 more
wiley   +1 more source

Expression level and glycan dynamics determine the net effects of TIMP-1 on cancer progression [PDF]

BMB Reports, 2012
Tissue inhibitor of metalloproteinases (TIMPs; TIMP-1, -2, -3 and-4) are endogenous inhibitor for matrix metalloproteinases(MMPs) that are responsible for remodeling the extracellularmatrix (ECM) and involved in migration, invasion and metastasisof tumor
Yong-Sam Kim, Sun-Hee Kim, Jeong-Gu Kang & Jeong-Heon Ko*
doaj  

Is the expression of matrix metalloproteinases (MMP-2, -9) and tissue inhibitors of metalloproteinases (TIMP-1, -2, and -3) associated with angiogenesis and clinicopathological features for breast cancer?

Journal of Health Sciences, 2017
Introduction: Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are involved in the progression of several tumors, including breast cancer. Our aim was to investigate the association of immunohistochemical expression of
Suada Kuskunović-Vlahovljak, Nina Čamdžić, Svjetlana Radović, Mirsad Dorić, Mirsad Babić, Edina Lazović Salčin, Lejla Džananović   +6 more
doaj   +1 more source

Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation. [PDF]

PLoS ONE, 2012
Prediction of therapeutic response and cancer patient survival can be improved by the identification of molecular markers including tumor Akt status. A direct correlation between NOS2 expression and elevated Akt phosphorylation status has been observed ...
Lisa A Ridnour, Kimberly M Barasch, Alisha N Windhausen, Tiffany H Dorsey, Michael M Lizardo, Harris G Yfantis, Dong H Lee, Christopher H Switzer, Robert Y S Cheng, Julie L Heinecke, Ernst Brueggemann, Harry B Hines, Chand Khanna, Sharon A Glynn, Stefan Ambs, David A Wink   +15 more
doaj   +1 more source

Outside the Wall: Hydrodynamics of Type I Supernovae Interacting with a Partially Swept-Up Circumstellar Medium

, 2020
Explaining the observed diversity of supernovae (SNe) and the physics of explosion requires knowledge of their progenitor stars, which can be obtained by constraining the circumstellar medium (CSM).
Harris, Chelsea E., Nugent, Peter E.
core   +2 more sources

Matrix metalloproteinases in liver injury, repair and fibrosis. [PDF]

, 2015
The liver is a large highly vascularized organ with a central function in metabolic homeostasis, detoxification, and immunity. Due to its roles, the liver is frequently exposed to various insults which can cause cell death and hepatic dysfunction ...
Baber, John, Coito, Ana J, Duarte, Sergio, Fujii, Takehiro   +3 more
core   +1 more source

Response of an Infant With Presumed Multiple Acyl‐CoA Dehydrogenase Deficiency (MADD) to Ketone Supplementation

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Multiple Acyl‐CoA Dehydrogenase Deficiency (MADD) is an autosomal recessive inborn error of metabolism caused by biallelic pathogenic variants in one of three known genes: ETFA, ETFB, and ETFDH. It can cause multisystem dysfunction, including cardiomyopathy in severe cases.
Yutaka Furuta, Kaitlyn N. Bloom, Jerry Vockley, Angela R. Grochowsky, Neena S. Agrawal, Ellen W. Strickler, Natalie N. Owen, Erica T. Gray, B. Lakshitha A. Perera, Eric R. Gamazon, Lynette C. Rives, Hua‐Chang Chen, Qi Liu, Rizwan Hamid, Joy D. Cogan, John A. Phillips III, Thomas A. Cassini, Bryce A. Schuler   +17 more
wiley   +1 more source

Localization of the Functional Domains of Human Tissue Inhibitor of Metalloproteinases-3 and the Effects of a Sorsby's Fundus Dystrophy Mutation [PDF]

, 1998
A transient COS-7 cell expression system was used to investigate the functional domain arrangement of tissue inhibitor of metalloproteinases-3 (TIMP-3), specifically to assess the contribution of the amino- and carboxylterminal domains of the ...
Barker, M.D., Langton, K.P., McKie, N.
core  

Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human achilles tendon [PDF]

, 2006
To profile the messenger RNA (mRNA) expression for the 23 known genes of matrix metalloproteinases (MMPs), 19 genes of ADAMTS, 4 genes of tissue inhibitors of metalloproteinases (TIMPs), and ADAM genes 8, 10, 12, and 17 in normal, painful, and ruptured ...
Alfredson, Alfredson, Amour, Amour, Anthony N. Corps, Archambault, Arnoczky, Asakura, Astrom, Baker, BenEzra, Bjur, Black, Brew, Brian L. Hazleman, Caroline J. Pennington, Cawston, Clancy, Conover, Dickinson, Drummond, Dylan R. Edwards, Fenwick, Gavin C. Jones, Graham P. Riley, Hannafin, Hashimoto, Hieta, Ian M. Clark, Iba, Iba, Ireland, Jarvinen, Jones, Jozsa, Kannus, Kashiwagi, Kashiwagi, Killar, Kurisaki, Lavagnino, Lo, Loechel, Ma, Majima, Malfait, Michelle M. Bradley, Movin, Mueller, Muller, Nakamura, Nuttall, Pei, Pendas, Porter, Primakoff, Rees, Riley, Riley, Riley, Roy, Sandy, Sandy, Sedlacek, Somerville, Sternlicht, Thodeti, Tipton, Tsuzaki, Van Meurs, Van Meurs, Velasco, Yasuda, Yu   +73 more
core   +1 more source