Results 81 to 90 of about 141,946 (275)

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Investigation of Tissue Inhibitor of Metalloproteinases 1 in Plasma from Colorectal Cancer Patients and Blood Donors by Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

The International Journal of Biological Markers, 2007
Early detection of colorectal cancer (CRC) improves patient survival. Plasma tissue inhibitor of metalloproteinases 1 (TIMP-1) measurements by enzyme-linked immunosorbent assay (ELISA) have been suggested as a new method for the early detection of CRC ...
M.B. Caspersen, N.M. Sørensen, A.S. Schrohl, P. Iversen, H.J. Nielsen, N. Brünner   +5 more
doaj   +2 more sources

Figure S3 from Tumor-Contacted Neutrophils Promote Metastasis by a CD90-TIMP-1 Juxtacrine–Paracrine Loop

, 2019
Figure S3 shows that TINs promote metastasis by TIMP-1.
Min Huang (161268), Shicheng Su (294982), Wei Wu (27708), Jianing Chen (491604), Ling Lin (57361), Ying Wang (11406), Linbin Yang (15017112), Jiaqian Li (669415)   +7 more
core   +1 more source

Diagnosis of Portal Hypertension: Advancing Towards Non‐Invasive Solutions

Portal Hypertension &Cirrhosis, EarlyView.
This review systematically summarizes a full spectrum of non‐invasive diagnostic approaches for portal hypertension (PH), including imaging modalities, elastography, serum biomarkers, composite scoring systems and endoscopic ultrasound‐guided portal pressure gradient (EUS‐PPG), and analyzes their performance across different liver disease etiologies ...
Lijia Yin, Huikuan Chu, Ling Yang
wiley   +1 more source

TIMP-1 signaling via CD63 triggers granulopoiesis and neutrophilia in mice

Haematologica, 2015
The homeostasis of neutrophil granulocytes can affect the outcome of several inflammation-associated diseases including cancer. The regulation of this homeostasis is still not completely understood.
Julia Kobuch, Haissi Cui, Barbara Grünwald, Paul Saftig, Percy A. Knolle, Achim Krüger   +5 more
doaj   +1 more source

Figure S4 from Tumor-Contacted Neutrophils Promote Metastasis by a CD90-TIMP-1 Juxtacrine–Paracrine Loop

, 2019
Figure S4 shows that TINs promote EMT by a CD90-TIMP-1 juxtacrineparacrine ...
Min Huang (161268), Shicheng Su (294982), Wei Wu (27708), Jianing Chen (491604), Ling Lin (57361), Ying Wang (11406), Linbin Yang (15017112), Jiaqian Li (669415)   +7 more
core   +1 more source

Genomics and epigenomics of tissue repair: Implications for personalized medicine

Precision Medical Sciences, EarlyView.
Genomic and epigenomic mechanisms govern tissue repair and regeneration through dynamic regulation of inflammation, cell fate, and extracellular matrix remodeling. The integration of multi‐omics, artificial intelligence, and precision regenerative therapies enables biomarker‐driven, personalized approaches to enhance healing and minimize fibrosis ...
Jharna Medhi, Chandrashekar Thalluri, Sarad Pawar Naik Bukke, Piyali Dey, Mallikarjun Vasam, Ananda Kumar Chettupalli, Swetha Kumari Koduru, Gali Avinash Kumar   +7 more
wiley   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

Tissue Inhibitor of Metalloproteinase-4 Triggers Apoptosis in Cervical Cancer Cells.

PLoS ONE, 2015
Tissue inhibitor of metalloproteinase-4 (TIMP-4) is a member of extracellular matrix (ECM) metalloproteinases inhibitors that has pleiotropic functions. However, TIMP-4 roles in carcinogenesis are not well understood.
Floria Lizarraga, Gisela Ceballos-Cancino, Magali Espinosa, Karla Vazquez-Santillan, Vilma Maldonado, Jorge Melendez-Zajgla   +5 more
doaj   +1 more source

TIMP-1 is a novel serum biomarker for the diagnosis of colorectal cancer: A meta-analysis - Fig 3

, 2018
Forest plots show the pooled sensitivity and specificity (a), the pooled positive likelihood ratio and negative likelihood ratio (b), the pooled diagnostic score and diagnostic odds ratio(c) for assessing the diagnostic value of TIMP-1in colorectal ...
Kaifeng Tang (5993231), Chunyan Meng (5993228), Hongchao Tang (5993234), Jingting Liu (2527606), Xiaowei Yin (2901710), Jianhua Liao (1393228)   +5 more
core   +1 more source