Results 161 to 170 of about 122,951 (264)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Conducting multicenter trials through the trial innovation network comprehensive consultation. [PDF]

Contemp Clin Trials
Hanley DF, Lane K, McBee N, Eyzaguirre LM, Mould WA, Holthouse E, Baird JF, Casey JD, Wilkins CH, Waddy SP, Wiley KL, Hassani S, Hildreth M, Nanni A, Edwards TL, Thompson DD, Stroud M, Serdoz E, Kennedy N, Nelson SJ, Jones M, Boone LR, Lawrence C, Cook SK, Chen T, Cohen J, Dilts N, Cheng AC, Grout RW, Miller ER, Casella JF, Benjamin DK, Selker HP, Palm ME, Poole L, Burr JS, Ford DE, Bernard GR, Harris PA.   +38 more
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Case Report: Pulmonary alveolar proteinosis and fibrosis associated with indium-tin-oxide exposure. [PDF]

Front Med (Lausanne)
Li X, Shi C, Chen Q, Zhao J, Wang S, Yin Y, Feng R, Tian X, Xu KF.   +8 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Extraintestinal Manifestations of Inflammatory Bowel Disease: A Focus on Kidney Complications. [PDF]

Int J Mol Sci
Wu H, Lin A, Chi J, Zhang J, Peng B, Ni D, Hao H, Liu Z.   +7 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Research Progress on the Influence of Surface Treatment Techniques on Fatigue Properties of Titanium Alloys. [PDF]

Materials (Basel)
Liu B, Zhang H, Wang X, Li Y, Li S, Cui X, Luhovskyi Y, Nong Z.   +7 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Recanalization of complex central venous occlusion in a hemodialysis patient with a functioning arteriovenous fistula. [PDF]

J Vasc Surg Cases Innov Tech
Tin LD, Thuy Vy TT, Bich Le TT, Le T.
europepmc   +1 more source