Results 31 to 40 of about 832 (140)

Predictive Analysis for First Submission of Generic Drug Application for Orphan Drug Products Using Random Survival Forest

Clinical and Translational Science, Volume 18, Issue 10, October 2025.
ABSTRACT Rare diseases affect a small population of patients, resulting in low incentives for developing orphan drug products (ODPs). The United States Congress passed the Orphan Drug Act of 1983 to incentivize pharmaceutical manufacturers to develop drugs to treat rare diseases.
Robert Hopefl, Jing Wang, Abhinav Ram Mohan, Wei‐Jhe Sun, Myong‐Jin Kim, Meng Hu, Lanyan Fang   +6 more
wiley   +1 more source

Asymmetric Strategies for the Synthesis of Enantiopure α‐/β‐/γ‐Thio‐Carboxylic Acids Bearing a Stereocentre at CS Bond

Advanced Synthesis &Catalysis, Volume 367, Issue 18, September 29, 2025.
Enantioenriched α‐/β‐/γ‐thiocarboxylic acids featuring C–S chirality are valuable targets in organic synthesis. This review outlines recent progress in their asymmetric synthesis, including chiral pool approaches, metal‐ /organo‐catalysis, and emerging biocatalytic strategies. Enantiomerically pure α‐/β‐/γ‐thiocarboxylic acids bearing a stereocentre at
Jingyue Wu, Daniele Castagnolo
wiley   +1 more source

A Case Report of Chlamydia Psittaci Pneumonia and Pulmonary Aspergillosis Diagnosed by Nanopore Sequencing

iLABMED, Volume 3, Issue 3, Page 258-262, September 2025.
ABSTRACT This paper reports a case of Chlamydia psittaci pneumonia and pulmonary aspergillosis with concurrent liver injury. The patient was admitted to the hospital with coughing, expectoration, and fever for 5 days. Laboratory tests upon admission revealed abnormalities in liver function.
Chang Song, Chunyan Zhao, Aichun Huang, Chaoyan Xu, Chunmei Zeng, Qingdong Zhu   +5 more
wiley   +1 more source

Nanocarrier‐Based Systems for Targeted Delivery: Current Challenges and Future Directions

MedComm, Volume 6, Issue 9, September 2025.
Recent advances in nanocarrier‐mediated delivery for nuclear targeting Cell nucleus: key target for improved therapeutic outcomes including chemotherapy, photodynamic therapy, and gene therapy Nuclear‐targeted drug delivery strategy: including nuclear localization sequence (NLS)‐mediated active targeting and passive strategies • Challenges in nuclear ...
Zichen Xu, Yongyi Xie, Wenjie Chen, Wei Deng   +3 more
wiley   +1 more source

Case Report: Nephrotic syndrome with minimal change disease during anti-tuberculosis treatment and tiopronin use

Frontiers in Medicine
BackgroundHepatoprotective agents are often added during prolonged anti-tuberculosis (anti-TB) therapy, and medication-associated nephrotic syndrome may be under-recognized.CaseA 31-year-old man with pulmonary tuberculosis received long-term anti-TB ...
Heng Liao, Heng Liao, Fei Yan, Fei Yan, Xingxia Liu   +4 more
doaj   +1 more source

Insulin Autoimmune Syndrome: A Chinese Expert Consensus Statement

AGING MEDICINE, Volume 8, Issue 1, February 2025.
ABSTRACT Insulin autoimmune syndrome (IAS) is a rare autoimmune disorder characterized by spontaneous hypoglycemia. The incidence of IAS is higher in East Asian populations compared to other populations. Delayed diagnosis and treatment can lead to recurrent hypoglycemia, significant glucose fluctuations, and adverse clinical outcomes, including life ...
Huabing Zhang, Ming Xia Yuan, Qi Pan
wiley   +1 more source

Meta‐analysis of probiotics efficacy in the treatment of minimum hepatic encephalopathy

Liver International, Volume 44, Issue 12, Page 3164-3173, December 2024.
Abstract Objective This study aims to systematically evaluate the efficacy of probiotics in treating minimum hepatic encephalopathy (MHE). Methods A systematic search was conducted across three major databases: PubMed, China National Knowledge Infrastructure and Wanfang. The search period spanned from the inception of each database to 9 March 2023. The
Yu‐Lian Zhou, Shu‐Tao Pu, Jian‐Bo Xiao, Jun Luo, Li Xue   +4 more
wiley   +1 more source

Unraveling Nanomaterials in Biomimetic Mineralization of Dental Hard Tissue: Focusing on Advantages, Mechanisms, and Prospects

Advanced Science, Volume 11, Issue 40, October 28, 2024.
Due to their nanoscale dimensions and excellent designability, nanomaterials can regulate the different stages of biomimetic mineralization of dental hard tissue. They play a corresponding role in the function of the raw materials for mineralization, mineralized microenvironment, mineralization guidance, and the function of mineralized products ...
Danni Dai, Dan Li, Chao Zhang
wiley   +1 more source

Prenatal diagnosis of cystinuria with a heterozygous pathogenic variant in SLC7A9 gene associated with isolated hyperechogenic fetal kidneys: A case report

Clinical Case Reports, Volume 12, Issue 7, July 2024.
Sagittal US scans of the left (A) and right (B) kidneys at 21 weeks and 6 days of gestation showing bilateral hyperechogenic nondifferentiated kidneys of normal size. Key Clinical Message Cystinuria is suspected antenatally by a hyperechogenic fetal colonic content.
Osaretin Pamela Aigbogun, Noémie Vancoppenolle, Sandra Coppens, Martina Marangoni, Elodie Elsen, Marie Cassart, Caroline Gounongbe   +6 more
wiley   +1 more source

Protective effects of tiopronin against oxidative stress in severely burned patients

Drug Design, Development and Therapy, 2019
Feng-Jun Qin, Xiao-Hua Hu, Zhong Chen, Xu Chen, Yu-Ming ShenDepartment of Burns, Beijing Jishuitan Hospital, Beijing, People’s Republic of ChinaObjective: Tiopronin is an antioxidant.
Qin FJ, Hu XH, Chen Z, Chen X, Shen YM
doaj