Results 41 to 50 of about 4,530,863 (282)

Global Tipping Points Report 2023: Ch1.2: Cryosphere tipping points. [PDF]

, 2023
Drastic changes in our planet’s frozen landscapes have occurred over recent decades, from Arctic sea ice decline and thawing of permafrost soils to polar amplification, the retreat of glaciers and ice loss from the ice sheets.
Aksenov, Yevgeny, Gasson, Ed, Armstrong McKay, David I., Kääb, Andreas, Klose, Ann Kristin, Brovkin, Victor, Robinson, Alex, Winkelmann, Ricarda, Nitzbon, Jan, Arndt, Sandra, Bathiany, Sebastian, Maussion, Fabien, Steinert, Norman J., Sudakow, Ivan, Garbe, Julius, Langebroek, Petra, Marzeion, Ben, Goelzer, Heiko, Burke, Eleanor, Notz, Dirk, Hugelius, Gustaf, Rynders, Stefanie   +21 more
core   +3 more sources

Oxidative stress-triggered Wnt signaling perturbation characterizes the tipping point of lung adeno-to-squamous transdifferentiation

Signal Transduction and Targeted Therapy, 2023
Lkb1 deficiency confers the Kras-mutant lung cancer with strong plasticity and the potential for adeno-to-squamous transdifferentiation (AST). However, it remains largely unknown how Lkb1 deficiency dynamically regulates AST.
Zhaoyuan Fang, Xiangkun Han, Yueqing Chen, Xinyuan Tong, Yun Xue, Shun Yao, Shijie Tang, Yunjian Pan, Yihua Sun, Xue Wang, Yujuan Jin, Haiquan Chen, Liang Hu, Lijian Hui, Lin Li, Luonan Chen, Hongbin Ji   +16 more
doaj   +1 more source

The Sustainability Tipping Point in Electricity Markets [PDF]

, 2017
Energy markets are currently in a state of uncertainty and flux, with the ongoing integration of volatile renewable energy sources. Where renewable resources provide sustainable benefits to achieve political targets, their recent sharp increase has ...
Koolen, Derck, Gupta, Alok, Gupta, A, Ketter, Wolfgang, Qui, Liangfei, Qiu, L, Qiu, Liangfei, Ketter, Wolf; id_orcid   +7 more
core  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Growth of Oxygen Minimum Zones May Indicate Approach of Global Anoxia

Mathematics
The dynamics of large-scale components of the Earth climate system (tipping elements), particularly the identification of their possible critical transitions and the proximity to the corresponding tipping points, has been attracting considerable ...
Yazeed Alhassan, Sergei Petrovskii
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

High probability of triggering climate tipping points under current policies modestly amplified by Amazon dieback and permafrost thaw [PDF]

Earth System Dynamics
We investigate the probabilities of triggering climate tipping points under five Shared Socioeconomic Pathways (SSPs) and how they are altered by including the additional carbon emissions that could arise from tipping points within the Earth's carbon ...
J. Deutloff, J. Deutloff, J. Deutloff, H. Held, T. M. Lenton   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Spatiotemporal Tipping Induced by Turing Instability and Hopf Bifurcation in a Population Ecosystem Model with the Fear Factor

Complexity, 2023
Population ecosystems can display the tipping points at which extinctions of species happens. To predict the appearance of tipping points and to understand their evolution mechanism are of uttermost importance for ecological balance.
Min Xiao, Gong Chen, Feilong Wang, Zunshui Cheng, Yi Yao   +4 more
doaj   +1 more source