Results 51 to 60 of about 4,530,863 (282)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

ESD Ideas: Climate tipping is not instantaneous – the duration of an overshoot matters [PDF]

Earth System Dynamics
Climate tipping points are not committed to occur automatically upon crossing critical thresholds in global warming, as is often assumed. Instead, it is possible to temporarily overshoot a threshold without causing tipping, provided the duration of the ...
P. D. L. Ritchie, P. D. L. Ritchie, C. Huntingford, P. M. Cox, P. M. Cox   +4 more
doaj   +1 more source

Close to the Tipping Point

Nursing Leadership, 2010
Nursing leaders play a critical role in creating and enacting a vision for collaborative practice with advanced practice nurses (APNs). In this special issue, Nancy Carter and colleagues have identified many important influences and outcomes of successful nursing leadership in the context of promoting advanced practice nursing roles. The authors make a
openaire   +3 more sources

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Global Tipping Points 2023 Report: Ch1.4 – Tipping points in ocean and atmosphere circulations. [PDF]

, 2023
This chapter assesses scientific evidence for tipping points across circulations in the ocean and atmosphere. The warming of oceans, modified wind patterns and increasing freshwater influx from melting ice hold the potential to disrupt established ...
Aksenov, Yevgeny, Armstrong McKay, David I., Fedorov, Alexey, Born, Andreas, Pausata, Francesco, Gala, Govindasamy, Jackson, Laura, Swingedouw, Didier, Sallée, JB, Dijkstra, Henk, Kornhuber, Kai, England, Matt, Drifjhout, Sybren, Chiessi, Cristiano M., Sherwood, Steven, Sinha, Bablu, Tharammal, Thejna, Rynders, Stefanie, Messori, Gabriele, Loriani, Sina   +19 more
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Time irreversibility as an indicator of approaching tipping points in Earth subsystems

Communications Earth & Environment
With shifting environmental trends, many Earth system elements may be poised to undergo critical transitions or ‘tipping’. Reliable anticipation of these tipping elements is vital to inform policy decisions.
Parvathi Kooloth, Jian Lu, Adam Rupe, Derek DeSantis, Craig Bakker   +4 more
doaj   +1 more source

Nevada: Change and the Political Tipping Point

California Journal of Politics and Policy, 2015
Nevada is experiencing structural change and a political tipping point.  The 2010 Census and reapportionment of the Nevada Legislature are the significant factors producing permanent political change in Nevada.
Robert Morin
doaj   +1 more source

Climate change induced socio-economic tipping points: review and stakeholder consultation for policy relevant research

Environmental Research Letters, 2020
Tipping points have become a key concept in research on climate change, indicating points of abrupt transition in biophysical systems as well as transformative changes in adaptation and mitigation strategies.
Kees C H van Ginkel, W J Wouter Botzen, Marjolijn Haasnoot, Gabriel Bachner, Karl W Steininger, Jochen Hinkel, Paul Watkiss, Esther Boere, Ad Jeuken, Elisa Sainz de Murieta, Francesco Bosello   +10 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source